mProX™ Human CHEK1 Stable Cell Line
[CAT#: S01YF-1123-KX193]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
CHEK1
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
HCC; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Cancer Research
Related Diseases
Ataxia-Telangiectasia and Li-Fraumeni Syndrome. Among its related pathways are Homology Directed Repair and Regulation of activated PAK-2p34 by proteasome mediated degradation
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
Chk1, also known as checkpoint kinase 1, is a serine/threonine-specific protein kinase that is encoded by the CHEK1 gene in humans. The cell cycle checkpoint response and the DNA damage response (DDR) are coordinated by Chk1. In order to stop injured cells from advancing through the cell cycle, Chk1 activation triggers the start of cell cycle checkpoints, cell cycle arrest, DNA repair, and cell death. In addition to being a crucial regulator of the cell cycle and cell survival, Chk1 is a fundamental part of genome surveillance pathways. In addition to being necessary for the start of DNA damage checkpoints, Chk1 has also been demonstrated to be involved in the regular (unperturbed) cell cycle. Chk1 affects the S phase, G2/M transition, and M phases of the cell cycle. The customized CHEK1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Sharon
This mouse CHEK1 cell line enabled us to conduct our experiments with confidence, and we achieved publication-worthy data.
Sep 01 2021
Verified Customer
Ronald
The CHEK1 cell line demonstrated remarkable specificity and sensitivity, which helped us unravel complex signaling pathways.
Oct 14 2022
Verified Customer
FAQ
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