CDK8
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
| Full Name | cyclin dependent kinase 8 |
| Gene ID | Human: 1024 Mouse: 264064 Rat: 498140 Monkey: 709761 |
| UniProt ID | Human: P49336 Mouse: Q8R3L8 Rat: A0A8I5ZVW8 |
| Alternative Names | K35; IDDHBA;cyclin-dependent kinase 8;CDK8 protein kinase;cell division protein kinase 8;mediator complex subunit CDK8;mediator of RNA polymerase II transcription subunit CDK8;protein kinase K35 |
Product List
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- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: CDK8/CycC Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CDK8 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
