mProX™ Human CDK8 Stable Cell Line
[CAT#: S01YF-1123-KX190]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
CDK8
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Cardiovascular Research; CNS Research
Related Diseases
Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities and Ebstein Anomaly. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription)
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The human CDK8 gene encodes the enzyme cell division protein kinase 8. This gene codes for a protein that belongs to the family of cyclin-dependent protein kinases, or CDKs. Through many processes, CDK8 and cyclin C regulate transcription by forming an association with the mediator complex. Many transcription factors are bound by CDK8 and/or phosphorylated, which can either activate or inhibit the action of the transcription factors. SREBP, STAT1 S727, and the Notch intracellular domain are all phosphorylated by CDK8. Additionally, through affecting the turnover of subunits in the mediator complex tail module, CDK8 prevents transcriptional activation. Furthermore, RNA polymerase II's interaction to the mediator complex is influenced by CDK8. The customized CDK8 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Sharon
This human CDK8 overexpression cell line is sensitive and specific. I definitely recommend this cell line.
Feb 19 2020
Verified Customer
Deborah
I must say that I am extremely impressed with its performance. The CDK8 cell line was easy to use and provided excellent results in my experiments.
Jun 14 2022
Verified Customer
FAQ
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