CDK5
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.
| Full Name | cyclin dependent kinase 5 |
| Gene ID | Human: 1020 Mouse: 12568 Rat: 140908 Monkey: 714445 |
| UniProt ID | Human: Q00535 Mouse: P49615 Rat: Q03114 |
| Alternative Names | LIS7; PSSALRE;cyclin-dependent kinase 5;TPKII catalytic subunit;cell division protein kinase 5;cyclin-dependent-like kinase 5;epididymis secretory sperm binding protein;protein kinase CDK5 splicing;serine/threonine-protein kinase PSSALRE;tau protein kinase II catalytic subunit |
Product List
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- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: CDK5/p25NCK Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: CDK5/p35NCK Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CDK5 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: HGC-27; CHO-K1; HEK293
