BMPR1B
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.
| Full Name | bone morphogenetic protein receptor type 1B |
| Gene ID | Human: 658 Mouse: 12167 Rat: 310914 Monkey: 705474 |
| UniProt ID | Human: O00238 Mouse: P36898 Rat: A0A8I5ZJI2 |
| Alternative Names | ALK6; AMD3; AMDD; BDA2; ALK-6; BDA1D; CDw293;bone morphogenetic protein receptor type-1B;BMP type-1B receptor;BMPR-1B;activin receptor-like kinase 6;bone morphogenetic protein receptor, type IB;serine/threonine receptor kinase |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BMPR1B Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
