mProX™ Human BMPR1B Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1037	Magic™ Human BMPR1B(ALK6) in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

BMPR1B

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Reproductive Research

Related Diseases

Acromesomelic Dysplasia 3 and Brachydactyly, Type A1, D. Among its related pathways are Akt Signaling and NF-kappaB Pathway.

Gene ID

658

UniProt ID

O00238

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human BMPR1B gene encodes the protein known as bone morphogenetic protein receptor type-1B, or CDw293. BMPR1B belongs to the family of transmembrane serine/threonine kinases known as the bone morphogenetic protein (BMP) receptor family. BMPs are the ligands for this receptor; they belong to the TGF-beta superfamily. Both embryogenesis and endochondral bone development are impacted by BMPs. Serine kinase receptors of two distinct types-type I and type II receptors-form heteromeric complexes that allow these proteins to transduce their signals. While type I receptors need their corresponding type II receptors for ligand binding, type II receptors can bind ligands in the absence of type I receptors. On the other hand, type I receptors need their corresponding type II receptors for signaling. The customized BMPR1B stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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The human BMPR1B cell line has played a pivotal role in our journey of discovery. Its reliable performance and consistent results have propelled our research forward. Jan 29 2023

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I've used the BMPR1B KO cell line in multiple assays, and each time, it has exceeded my expectations. Jan 17 2023

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Results of luciferase activity analyses.

The assay results showed that co-transfection with miR-1306 mimics significantly decreased the luciferase activity in cells containing the wild-type vector, suggesting that miR-1306 can suppress the transcriptional activity of the 3'-UTR region of BMPR1B.

Ref: Abdurahman, Anwar, et al. "miR-1306 induces cell apoptosis by targeting BMPR1B gene in the ovine granulosa cells." Frontiers in Genetics 13 (2022): 989912.

Pubmed: 36212145

DOI: 10.3389/fgene.2022.989912

Research Highlights

Of women under 40, 1% suffer from the often occurring condition known as primary ovarian insufficiency (POI). Infertility results from POI, which is characterized by early ovarian follicle depletion and increased follicle-stimulating hormone plasma levels.
Renault, Lucie, et al. "BMPR1A and BMPR1B missense mutations cause primary ovarian insufficiency." The Journal of Clinical Endocrinology & Metabolism 105.4 (2020): e1449-e1457.
Pubmed: 31769494 DOI: 10.1210/clinem/dgz226

One of the primary genes that can be employed as a molecular genetic marker for the early selection of ewes with high productivity is BMPRIB. The initial mutation in the kinase domain of the BMPR1B gene, p.Q249R (g.746A> G), is well-documented and strongly associated with higher ovulation rate and litter size.
Akhatayeva, Zhanerke, et al. "Survey of the relationship between polymorphisms within the BMPR1B gene and sheep reproductive traits." Animal Biotechnology 34.3 (2023): 718-727.
Pubmed: 34586970 DOI: 10.1080/10495398.2021.1979023