BCR
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.
| Full Name | BCR activator of RhoGEF and GTPase |
| Gene ID | Human: 613 Mouse: 110279 Rat: 309696 Monkey: 709258 |
| UniProt ID | Human: P11274 Mouse: Q6PAJ1 Rat: F1LXF1 Monkey: F6Y8F5 |
| Alternative Names | ALL; CML; PHL; BCR1; D22S11; D22S662; breakpoint cluster region protein; BCR, RhoGEF and GTPase activating protein; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; breakpoint cluster region; renal carcinoma antigen NY-REN-26 |
Product List
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Magic™ Human BCR & ABL (A337V) BaF3 Cell Line
[CAT#: S01YF-0324-KX147]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (A337V) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (E255K) BaF3 Cell Line
[CAT#: S01YF-1222-KX679]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255K) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (E255K, V299L) BaF3 Cell Line
[CAT#: S01YF-1222-KX630]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255K, V299L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (E255V) BaF3 Cell Line
[CAT#: S01YF-1222-KX678]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (E255V, T315I) BaF3 Cell Line
[CAT#: S01YF-0324-KX148]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255V, T315I) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (E355G) BaF3 Cell Line
[CAT#: S01YF-0324-KX149]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E355G) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (E459K) BaF3 Cell Line
[CAT#: S01YF-1222-KX638]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E459K) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317C) BaF3 Cell Line
[CAT#: S01YF-1222-KX673]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317C) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317I) BaF3 Cell Line
[CAT#: S01YF-1222-KX672]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317L) BaF3 Cell Line
[CAT#: S01YF-1222-KX671]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317V) BaF3 Cell Line
[CAT#: S01YF-1222-KX670]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359C) BaF3 Cell Line
[CAT#: S01YF-1222-KX665]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359C) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359I) BaF3 Cell Line
[CAT#: S01YF-1222-KX666]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359L) BaF3 Cell Line
[CAT#: S01YF-1222-KX667]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359V) BaF3 Cell Line
[CAT#: S01YF-1222-KX641]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (G250E) BaF3 Cell Line
[CAT#: S01YF-1222-KX680]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (G250E) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (H396P) BaF3 Cell Line
[CAT#: S01YF-1222-KX664]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (H396P) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (I502L) BaF3 Cell Line
[CAT#: S01YF-0324-KX150]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (I502L) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (K294E) BaF3 Cell Line
[CAT#: S01YF-0324-KX151]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (K294E) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (M244V) BaF3 Cell Line
[CAT#: S01YF-1222-KX639]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (M244V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (M351T) BaF3 Cell Line
[CAT#: S01YF-1222-KX663]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (M351T) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (P223S) BaF3 Cell Line
[CAT#: S01YF-0324-KX152]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (P223S) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (P465S) BaF3 Cell Line
[CAT#: S01YF-0324-KX153]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (P465S) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (Q252H) BaF3 Cell Line
[CAT#: S01YF-0324-KX155]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (Q252H) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (Q252H, T315I) BaF3 Cell Line
[CAT#: S01YF-0324-KX154]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (Q252H, T315I) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (T315I) BaF3 Cell Line
[CAT#: S01YF-1222-KX864]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, E459K) BaF3 Cell Line
[CAT#: S01YF-1222-KX634]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, E459K) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, F317L) BaF3 Cell Line
[CAT#: S01YF-1222-KX629]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, F317L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, F359V) BaF3 Cell Line
[CAT#: S01YF-1222-KX637]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, F359V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, M244V) BaF3 Cell Line
[CAT#: S01YF-1222-KX636]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, M244V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
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