BCR
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.
| Full Name | BCR activator of RhoGEF and GTPase |
| Gene ID | Human: 613 Mouse: 110279 Rat: 309696 Monkey: 709258 |
| UniProt ID | Human: P11274 Mouse: Q6PAJ1 Rat: F1LXF1 Monkey: F6Y8F5 |
| Alternative Names | ALL; CML; PHL; BCR1; D22S11; D22S662; breakpoint cluster region protein; BCR, RhoGEF and GTPase activating protein; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; breakpoint cluster region; renal carcinoma antigen NY-REN-26 |
Product List
Loading...
Magic™ Human BCR & ABL (A337V) BaF3 Cell Line
[CAT#: S01YF-0324-KX147]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (A337V) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (E255K) BaF3 Cell Line
[CAT#: S01YF-1222-KX679]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255K) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (E255K, V299L) BaF3 Cell Line
[CAT#: S01YF-1222-KX630]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255K, V299L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (E255V) BaF3 Cell Line
[CAT#: S01YF-1222-KX678]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (E255V, T315I) BaF3 Cell Line
[CAT#: S01YF-0324-KX148]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255V, T315I) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (E355G) BaF3 Cell Line
[CAT#: S01YF-0324-KX149]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E355G) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (E459K) BaF3 Cell Line
[CAT#: S01YF-1222-KX638]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E459K) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317C) BaF3 Cell Line
[CAT#: S01YF-1222-KX673]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317C) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (H396P) BaF3 Cell Line
[CAT#: S01YF-1222-KX664]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (H396P) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (I502L) BaF3 Cell Line
[CAT#: S01YF-0324-KX150]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (I502L) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (K294E) BaF3 Cell Line
[CAT#: S01YF-0324-KX151]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (K294E) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (M244V) BaF3 Cell Line
[CAT#: S01YF-1222-KX639]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (M244V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (M351T) BaF3 Cell Line
[CAT#: S01YF-1222-KX663]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (M351T) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (P223S) BaF3 Cell Line
[CAT#: S01YF-0324-KX152]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (P223S) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (P465S) BaF3 Cell Line
[CAT#: S01YF-0324-KX153]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (P465S) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (Q252H) BaF3 Cell Line
[CAT#: S01YF-0324-KX155]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (Q252H) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (F317I) BaF3 Cell Line
[CAT#: S01YF-1222-KX672]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317L) BaF3 Cell Line
[CAT#: S01YF-1222-KX671]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317V) BaF3 Cell Line
[CAT#: S01YF-1222-KX670]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359C) BaF3 Cell Line
[CAT#: S01YF-1222-KX665]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359C) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359I) BaF3 Cell Line
[CAT#: S01YF-1222-KX666]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359L) BaF3 Cell Line
[CAT#: S01YF-1222-KX667]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359V) BaF3 Cell Line
[CAT#: S01YF-1222-KX641]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (G250E) BaF3 Cell Line
[CAT#: S01YF-1222-KX680]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (G250E) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (Q252H, T315I) BaF3 Cell Line
[CAT#: S01YF-0324-KX154]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (Q252H, T315I) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human BCR & ABL (T315I) BaF3 Cell Line
[CAT#: S01YF-1222-KX864]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, E459K) BaF3 Cell Line
[CAT#: S01YF-1222-KX634]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, E459K) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, F317L) BaF3 Cell Line
[CAT#: S01YF-1222-KX629]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, F317L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, F359V) BaF3 Cell Line
[CAT#: S01YF-1222-KX637]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, F359V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, M244V) BaF3 Cell Line
[CAT#: S01YF-1222-KX636]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, M244V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Can't find the products you're looking for? Optimize our parameters for better results.
Filter By Tag
Note: All of our products are for Research Use Only (RUO). NOT intended for diagnostic, therapeutic or clinical use. We DO NOT offer patients any direct products or services. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
