BCR
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.
| Full Name | BCR activator of RhoGEF and GTPase |
| Gene ID | Human: 613 Mouse: 110279 Rat: 309696 Monkey: 709258 |
| UniProt ID | Human: P11274 Mouse: Q6PAJ1 Rat: F1LXF1 Monkey: F6Y8F5 |
| Alternative Names | ALL; CML; PHL; BCR1; D22S11; D22S662; breakpoint cluster region protein; BCR, RhoGEF and GTPase activating protein; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; breakpoint cluster region; renal carcinoma antigen NY-REN-26 |
Product List
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Human BCR & ABL Membrane Protein Bacterial Expression Plasmid
[CAT#: S01YF-1124-KX696]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme Vector: pBE Vector Type: Bacterial Expression Vector
Human BCR & ABL Membrane Protein In Vitro Transcription (IVT) mRNA
[CAT#: S01YF-1124-KX121]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme RNA Type: IVT mRNA Formation: In Vitro Transcription (IVT) mRNA
Human BCR & ABL Membrane Protein In Vitro Transcription (IVT) Plasmid
[CAT#: S01YF-1124-KX1041]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme Vector: pIVT Vector Type: In Vitro Transcription (IVT) Vector
Human BCR & ABL Membrane Protein Insect Expression Plasmid
[CAT#: S01YF-1124-KX466]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme Vector: pIE Vector Type: Insect Expression Vector
Human BCR & ABL Membrane Protein Lentiviral Expression Plasmid
[CAT#: S01YF-1124-KX811]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme Vector: pLV Vector Type: Lentiviral Expression Vector
Human BCR & ABL Membrane Protein Lentivirus
[CAT#: S01YF-1124-KX6]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme
Human BCR & ABL Membrane Protein LNP Encapsulation mRNA
[CAT#: S01YF-1124-KX236]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme RNA Type: LNP-mRNA Formation: LNP Encapsulation mRNA
Human BCR & ABL Membrane Protein Mammalian Transient Expression Plasmid
[CAT#: S01YF-1124-KX351]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme Vector: pME Vector Type: Mammalian Transient Expression Vector
Magic™ Human BCR & ABL (F317L) BaF3 Cell Line
[CAT#: S01YF-1222-KX671]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317V) BaF3 Cell Line
[CAT#: S01YF-1222-KX670]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359C) BaF3 Cell Line
[CAT#: S01YF-1222-KX665]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359C) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359I) BaF3 Cell Line
[CAT#: S01YF-1222-KX666]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359L) BaF3 Cell Line
[CAT#: S01YF-1222-KX667]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F359V) BaF3 Cell Line
[CAT#: S01YF-1222-KX641]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F359V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (G250E) BaF3 Cell Line
[CAT#: S01YF-1222-KX680]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (G250E) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (H396P) BaF3 Cell Line
[CAT#: S01YF-1222-KX664]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (H396P) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (M244V) BaF3 Cell Line
[CAT#: S01YF-1222-KX639]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (M244V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (M351T) BaF3 Cell Line
[CAT#: S01YF-1222-KX663]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (M351T) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I) BaF3 Cell Line
[CAT#: S01YF-1222-KX864]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, E459K) BaF3 Cell Line
[CAT#: S01YF-1222-KX634]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, E459K) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, F317L) BaF3 Cell Line
[CAT#: S01YF-1222-KX629]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, F317L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (T315I, F359V) BaF3 Cell Line
[CAT#: S01YF-1222-KX637]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (T315I, F359V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Human BCR & ABL Membrane Protein Retroviral Expression Plasmid
[CAT#: S01YF-1124-KX926]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme Vector: pRV Vector Type: Retroviral Expression Vector
Human BCR & ABL Membrane Protein Yeast Expression Plasmid
[CAT#: S01YF-1124-KX581]
- Product Category:
- Membrane Protein Tools
- Target Protein: BCR; ABL Target Family: Kinases/Enzyme Vector: pYE Vector Type: Yeast Expression Vector
Magic™ Human BCR & ABL (E255K) BaF3 Cell Line
[CAT#: S01YF-1222-KX679]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255K) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (E255K, V299L) BaF3 Cell Line
[CAT#: S01YF-1222-KX630]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255K, V299L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (E255V) BaF3 Cell Line
[CAT#: S01YF-1222-KX678]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E255V) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (E459K) BaF3 Cell Line
[CAT#: S01YF-1222-KX638]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (E459K) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317C) BaF3 Cell Line
[CAT#: S01YF-1222-KX673]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317C) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human BCR & ABL (F317I) BaF3 Cell Line
[CAT#: S01YF-1222-KX672]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & ABL (F317I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
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