Human BCR & ABL Membrane Protein In Vitro Transcription (IVT) Plasmid
[CAT#: S01YF-1124-KX1041]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein Plasmid Products
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order plasmid encoding human BCR & ABL for In Vitro Transcription.
Target Protein
BCR; ABL
Target Protein Species
Human
Target Classification
Kinases/Enzyme
Target Research Area
Autoimmune Research; Cancer Research
Related Diseases
Leukemia
Target Family
Kinases/Enzyme
Vector
pIVT
Vector Type
In Vitro Transcription (IVT) Vector
Note
Resistance
KanR
Growth Temperature
37°C
Relevant Promoters
T7
Mutation
Based on specific requirements
Expressed Tags
Based on specific requirements (Flag, StrepII, His, etc.)
Product Properties
Applications
In Vitro Transcription
Shipping
Blue Ice
Storage
Aliquot and store at -20°C for long term.
Target
Full Name
BCR activator of RhoGEF and GTPase
Introduction
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.
Alternative Names
ALL; CML; PHL; BCR1; D22S11; D22S662; breakpoint cluster region protein; BCR, RhoGEF and GTPase activating protein; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; breakpoint cluster region; renal carcinoma antigen NY-REN-26
Gene ID
UniProt ID
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