AXL
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.
| Full Name | AXL receptor tyrosine kinase |
| Gene ID | Human: 558 Mouse: 26362 Rat: 308444 Monkey: 706123 |
| UniProt ID | Human: P30530 Mouse: Q00993 Rat: Q8VI99 |
| Alternative Names | ARK; UFO; JTK11; Tyro7;tyrosine-protein kinase receptor UFO;AXL oncogene;AXL transforming sequence/gene |
Product List
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Magic™ Human AXL BaF3 Cell Line
[CAT#: S01YF-1222-KX826]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: AXL Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
mProX™ Human AXL Stable Cell Line
[CAT#: S01YF-1123-KX154]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: AXL Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
Magic™ Human AXL & MBIP BaF3 Cell Line
[CAT#: S01YF-0324-KX146]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: AXL & MBIP Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
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