mProX™ Human AXL Stable Cell Line

Product Information

Target Protein

AXL

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Immunology Research; Digestive and Renal Research; Reproductive Research

Related Diseases

Hypogonadotropic Hypogonadism 7 With Or Without Anosmia and Nk-Cell Enteropathy. Among its related pathways are GPCR Pathway and p70S6K Signaling

Gene ID

558

UniProt ID

P30530

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The AXL gene in humans is responsible for encoding the enzyme tyrosine-protein kinase receptor. The original designation of the gene, UFO, was a reference to the unknown purpose of this protein. But since its discovery, studies on the mechanism and expression profile of AXL have made it a more desirable target, particularly for cancer treatments. Recent research has shown that AXL plays a critical role in immune escape and treatment resistance in cancer cells, which can result in aggressive and metastatic malignancies. AXL is a member of the TAM family of kinases, which also includes TYRO3 and MERTK. It is a cell surface receptor tyrosine kinase. The customized AXL stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Colbert

We have found this AXL cell line to be highly reliable and robust, producing consistent results. Oct 15 2022

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chat Tobey

High quality and reliable AXL cell line. Dec 09 2022

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FAQ

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Published Data

Fig.1 Expression of Axl in malignant glioma cells.

Three neuroblastoma cell lines (JMR32, SKSNH, and SHSY5Y) and one medulloblastoma cell line (TE671) were nonglial, neoplastic cell lines in which Axl mRNA expression levels were not increased. Northern analysis verified the findings obtained from the array analysis.

Ref: Vajkoczy, Peter, et al. "Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival." Proceedings of the National Academy of Sciences 103.15 (2006): 5799-5804.

Pubmed: 16585512

DOI: 10.1073/pnas.0510923103

Research Highlights

These findings suggest that AXL is expressed preferentially in tumor cells that are resistant to treatment, and that cotargeting AXL in this situation may be able to overcome medication resistance. In the clinic, AXL inhibitor use must to be taken into consideration.
Scaltriti, Maurizio, Moshe Elkabets, and José Baselga. "Molecular pathways: AXL, a membrane receptor mediator of resistance to therapy." Clinical Cancer Research 22.6 (2016): 1313-1317.
Pubmed: 26763248 DOI: 10.1158/1078-0432.CCR-15-1458

For many years, the field of cancer research has focused heavily on molecularly targeted therapy. Growth arrest-specific protein 6 (GAS6) is a high-affinity ligand that is present in AXL, a member of the TAM family.
Zhu, Chenjing, Yuquan Wei, and Xiawei Wei. "AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications." Molecular cancer 18 (2019): 1-22.
Pubmed: 31684958 DOI: 10.1186/s12943-019-1090-3