ADGRE5
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.
| Full Name | Adhesion G protein-coupled receptor E5 |
| Gene ID | Human: 976 Mouse: 26364 Rat: 361383 Monkey: 100426363 |
| UniProt ID | Human: P48960 Mouse: Q9Z0M6 Rat: Q5XI36 Monkey: F6TY46 |
| Alternative Names | ADGRE5; CD97; TM7LN1; CD97 molecule; leukocyte antigen CD97; seven transmembrane helix receptor; seven-span transmembrane protein; seven-transmembrane, heterodimeric receptor associated with inflammation; Adhesion G protein-coupled receptor E5 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ADGRE5 Target Family: Orphan Family Target Protein Species: Human Host Cell Type: HT1080; CHO-K1; HEK293
