ABL1
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
| Full Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
| Gene ID | Human: 25 Mouse: 11350 Rat: 311860 Monkey: 722449 |
| UniProt ID | Human: P00519 Mouse: P00520 Rat: E9PT20 |
| Alternative Names | ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl; tyrosine-protein kinase ABL1;ABL protooncogene 1 nonreceptor tyrosine kinase; Abelson tyrosine-protein kinase 1; BCR-ABL1 p190; BCR/ABL e8a2 fusion; BCR/ABL1 e1a2 fusion protein; bcr/c-abl oncogene protein; c-abl oncogene 1, receptor tyrosine kinase; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ABL1 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: K562; Jurkat; CHO-K1; HEK293
