ABCG2
This gene encodes a membrane-associated protein that belongs to the ABC (ATP-binding cassette) transporter superfamily. Different substances are transported across extracellular and intracellular membranes by ABC proteins. The White subfamily includes this protein. This protein, which is also known as a breast cancer resistance protein, serves as a xenobiotic transporter and may be a key factor in multi-drug resistance. In reaction to exposure to mitoxantrone and anthracyclines, it probably acts as a cellular defense mechanism. This molecule may play a role in placenta tissue based on the significant expression of this protein that has been seen there.
| Full Name | ATP binding cassette subfamily G member 2 (Junior blood group) |
| Gene ID | Human: 9429 Mouse: 26357 Rat: 312382 Monkey: 102140529 |
| UniProt ID | Human: Q9UNQ0 Mouse: Q7TMS5 Rat: Q80W57 Monkey: Q5MB13 |
| Alternative Names | MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; UAQTL1; EST157481; broad substrate specificity ATP-binding cassette transporter ABCG2; ABC transporter; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group); breast cancer resistance protein; mitoxantrone resistance-associated protein; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; placenta specific MDR protein; placenta-specific ATP-binding cassette transporter; urate exporter; ABCG2; ATP binding cassette subfamily G member 2 (Junior blood group) |
Product List
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Magic™ Human ABCG2 Drug screening assay
[CAT#: S01YF-0922-KX1555]
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: ABCG2 Target Family: ABC Transporter Target Protein Species: Human Host Cell Type: Caco-2, MDCK, HEK293, CHO, membrane vesicles, and various transfected cells lines Assay Types: Activity Assay (High throughput screening assays; Large scale single dose, duplicate profiling; IC50 profiling; Ki determination assay; Substrate determination assay )
mProX™ Human ABCG2 Stable Cell Line
[CAT#: S01YF-1123-KX116]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ABCG2 Target Family: ABC Transporter Target Protein Species: Human Host Cell Type: NSCLC; CHO-K1; HEK293
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