ABCC2
The ATP-binding cassette (ABC) transporter superfamily includes the protein that this gene encodes. Different substances are transported across extracellular and intracellular membranes by ABC proteins. The MRP subfamily, which is implicated in multi-drug resistance, includes this protein as a member. This protein has a role in biliary transport and is expressed in the canalicular (apical) region of the hepatocyte. This protein thus appears to contribute to drug resistance in mammalian cells by being a substrate for substances such as anticancer medications like vinblastine. Patients with Dubin-Johnson syndrome (DJS), an autosomal recessive condition characterized by conjugated hyperbilirubinemia, have been shown to have a number of distinct mutations in this gene.
| Full Name | ATP binding cassette subfamily C member 2 |
| Gene ID | Human: 1244 Mouse: 12780 Rat: 25303 Monkey: 574169 |
| UniProt ID | Human: Q92887 Mouse: Q8VI47 Rat: Q63120 Monkey: F7GVK9 |
| Alternative Names | DJS; MRP2; cMRP; ABC30; CMOAT; canalicular multispecific organic anion transporter 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multidrug resistance protein; multidrug resistance-associated protein 2; ABCC2; ATP binding cassette subfamily C member 2 |
Product List
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- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: ABCC2 Target Family: ABC Transporter Target Protein Species: Human Host Cell Type: Caco-2, MDCK, HEK293, CHO, membrane vesicles, and various transfected cells lines Assay Types: Activity Assay (High throughput screening assays; Large scale single dose, duplicate profiling; IC50 profiling; Ki determination assay; Substrate determination assay )
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ABCC2 Target Family: ABC Transporter Target Protein Species: Human Host Cell Type: CNE2; CHO-K1; HEK293
