ABCB11
This gene encodes a membrane-associated protein that belongs to the superfamily of ATP-binding cassette (ABC) transporters. Different substances are transported across extracellular and intracellular membranes by ABC proteins. The MDR/TAP subfamily contains this protein as a member. The multidrug resistance of the MDR/TAP subfamily is a factor. The main canalicular bile salt export pump in humans is a protein that is expressed by this gene. A kind of progressive familial intrahepatic cholestases, a category of inherited illnesses with severe cholestatic liver disease from early childhood, are brought on by mutations in this gene.
| Full Name | ATP binding cassette subfamily B member 11 |
| Gene ID | Human: 8647 Mouse: 27413 Rat: 83569 Monkey: 709261 |
| UniProt ID | Human: O95342 Mouse: Q9QY30 Rat: O70127 Monkey: F6SYV4 |
| Alternative Names | BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2; bile salt export pump; ABC member 16, MDR/TAP subfamily; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein; ABCB11; ATP binding cassette subfamily B member 11 |
Product List
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Magic™ Human ABCB11 Drug screening assay
[CAT#: S01YF-0922-KX1560]
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: ABCB11 Target Family: ABC Transporter Target Protein Species: Human Host Cell Type: Caco-2, MDCK, HEK293, CHO, membrane vesicles, and various transfected cells lines Assay Types: Activity Assay (High throughput screening assays; Large scale single dose, duplicate profiling; IC50 profiling; Ki determination assay; Substrate determination assay )
mProX™ Human ABCB11 Stable Cell Line
[CAT#: S01YF-1123-KX121]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ABCB11 Target Family: ABC Transporter Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
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