mProX™ Human WNK1 Stable Cell Line

[CAT#: S01YF-1023-PY130]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX525	Magic™ Human WNK1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HeLa

Target Classification

Kinase Cell Lines

Target Research Area

Metabolic Research

Related Diseases

Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Pseudohypoaldosteronism, Type Iic

Gene ID

Human:65125

UniProt ID

Human:Q9H4A3

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The applications of WNK1 include its role in inhibiting the insulin-dependent AKT/WNK1 pathway to induce autophagy in mice with type 2 diabetes, its involvement in hereditary sensory and autonomic neuropathy type 2A (HSAN2A) and the regulation of pain-sensing dorsal root ganglion neurons, its contribution to lenvatinib resistance in hepatocellular carcinoma through the regulation of lysine-deficient kinase 1, and its association with essential hypertension risk in the Northern Han Chinese population.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Smith (Verified Customer)

What is the role of WNK1 in regulating NLRP3 inflammasome activation? Mar 07 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

WNK1 pathway suppresses NLRP3 activation, indicating its critical function in immune response and potential implications in hypertension treatment. Mar 07 2020

chat Casey Garcia (Verified Customer)

How does WNK1 contribute to cancer metastasis and angiogenesis? Dec 25 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

WNK1 is involved in cancer metastasis and angiogenesis, suggesting its targeting as a potential anti-cancer strategy. Dec 25 2021

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