mProX™ Human WNK1 Stable Cell Line

Suzuki, Takahiro. et al. "Trapa Bispinosa Roxb. Inhibits the Insulin-Dependent AKT/WNK1 Pathway to Induce Autophagy in Mice with Type 2 Diabetes." Diabetes, metabolic syndrome and obesity : targets and therapy, 2023.
The current study aims to explore the potential antiglycation properties of Trapa bispinosa Roxb. extract (TBE) and investigate its mechanism of action in a mouse model with type 2 diabetes. TBE,Äôs activity will be evaluated through in vivo experimentation, using diabetic mice as the subjects. This approach will contribute to a better understanding of the anti-diabetic potential of TBE and its constituents. The results may have significant implications in the development of novel therapeutic agents for managing diabetes.
Suzuki, Takahiro. et al. "Trapa Bispinosa Roxb. Inhibits the Insulin-Dependent AKT/WNK1 Pathway to Induce Autophagy in Mice with Type 2 Diabetes." Diabetes, metabolic syndrome and obesity : targets and therapy, 2023.
Pubmed: 37818405   DOI: 10.2147/DMSO.S430132

R Sapio, Matthew. et al. "Expression pattern analysis and characterization of the hereditary sensory and autonomic neuropathy 2 A (HSAN2A) gene with no lysine kinase (WNK1) in human dorsal root ganglion." Experimental neurology, 2023.
Inherited painless neuropathies result from genetic defects that disrupt the function or cause the destruction of sensory neurons in the dorsal root ganglion (DRG), leading to an inability to sense pain. Hereditary sensory and autonomic neuropathy type 2 (HSNAII) is a rare genetic disorder caused by mutations in the WNK1 gene. Specifically, mutations in the "HSN2" region, encoding a C-terminal domain of the WNK1 protein, have been linked to this condition. This study aimed to investigate the expression patterns of WNK1 and its splice variants in DRG and spinal cord tissues using multi-fluorescent RNA labeling. Despite initially hypothesizing that these transcripts would be enriched in nociceptive neurons, further analysis showed widespread expression, with some subpopulations of DRG neurons demonstrating higher levels of expression. This data suggests that HSN2-WNK1 may play a role in axon maintenance or that nociceptive neurons may be more susceptible to genetic insults. These findings provide insight into the expression of a painless neuropathy gene in humans.
R Sapio, Matthew. et al. "Expression pattern analysis and characterization of the hereditary sensory and autonomic neuropathy 2 A (HSAN2A) gene with no lysine kinase (WNK1) in human dorsal root ganglion." Experimental neurology, 2023.
Pubmed: 37793538   DOI: 10.1016/j.expneurol.2023.114552