mProX™ Human TRPM8 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Chemical ligands like menthol and icilin activate TRPM8, a temperature-sensing TRP channel. Although it is extensively expressed in prostate tissue, its exact function is yet unknown. Both trigeminal and dorsal root ganglia express TRPM8 functionally. TRPM8 is a key player in the sensory nerve system's ability to detect cold and regulate body temperature. In the endocrine pancreas, TRPM8 is not expressed. Nevertheless, TRPM8-deficient mice have elevated insulin sensitivity, which can be attributed to a compensatory mechanism that follows TRPM8−/− mice's higher insulin clearance. One compensatory mechanism that may arise from the loss of TRPM8-mediated neuronal impulses in hepatic neural innervations is the up-regulation of the insulin-degrading enzyme (IDE) in the liver. The hepatic vein is innervated by TRPM8 positive sensory afferents. TRPM8 may be a useful biomarker for pancreatic adenocarcinoma, as it has recently been linked to the disease. The customized TRPM8 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.