mProX™ Human TRPM4 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
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Published Data
Fig.1 TRPM4 expression affects protein levels and phosphorylation status of β-catenin.
In comparison to nontumoral RWPE-1 prostate cells, PC3 WT and LNCaP WT cells exhibit higher mRNA expression of the TRPM4 gene. RT-qPCR was run three times or more.
Ref: Sagredo, Alfredo I., et al. "TRPM 4 regulates Akt/GSK 3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells." Molecular Oncology 12.2 (2018): 151-165.
Research Highlights
TRPM4, also known as transient receptor potential melastatin subfamily member 4, is a monovalent-selective cation channel that is broadly distributed and triggered by calcium. Gene mutations affecting human TRPM4 (hTRPM4) cause a family history of progressive heart block.
Duan, Jingjing, et al. "Structure of full-length human TRPM4." Proceedings of the National Academy of Sciences 115.10 (2018): 2377-2382.
Pubmed:
29463718
DOI:
10.1073/pnas.1722038115
Calcium homeostasis is influenced by the transient receptor potential cation channel subfamily M member 4 (TRPM4) channel throughout a variety of physiological processes, including insulin secretion, immunological response, respiratory response, and cerebral vasoconstriction.
Wang, Chen, Keiji Naruse, and Ken Takahashi. "Role of the TRPM4 channel in cardiovascular physiology and pathophysiology." Cells 7.6 (2018): 62.
Pubmed:
29914130
DOI:
10.3390/cells7060062
