mProX™ Human TRPC1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TRPC1 is a cation channel that is widely expressed and lacks selectivity. It has been suggested that TRPC1, along with Orai1 and STIM1, is involved in store-operated calcium entrance. In a range of cell types, TRPC1 plays a crucial role in agonist-, growth factor-, and protein kinase C (PKC)-induced Ca2 + entry. It also contributes to several other vital physiological processes. It has also been demonstrated that TRPC1 is involved in the migration and proliferation of cancer cells. It has been observed that glioma cell chemotaxis in response to stimuli like epidermal growth factor (EGF) requires the TRPC1 channel. According to a different study, gliomas with TRPC1 deletion had inadequate cytokinesis, which resulted in cell growth halt. It has also been shown that TRPC1 depletion inhibits the proliferation of non-small-cell lung cancer cells. In human breast cancer epithelial primary culture, TRPC1 was shown to be overexpressed and has been linked to a proliferative phenotype in the disease. The customized TRPC1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.