mProX™ Human TRHR Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 The production of a punctate vesicular location of -arrestin 1-GFP is dependent on effective internalization of the TRHR-1 truncation mutants.
Either mock transfected or -arrestin 1-GFP (green)-expressing HEK293 cells were used. The cells were given a vehicle or TRH (1 M, 60 min) treatment before being fixed without permeabilization and labeled with an anti-VSV monoclonal antibody and a secondary antiserum that was Alexa 594-labeled (red).
Ref: Groarke, D. Alex, et al. "Analysis of the C-terminal tail of the rat thyrotropin-releasing hormone receptor-1 in interactions and cointernalization with β-arrestin 1-green fluorescent protein." Molecular Pharmacology 59.2 (2001): 375-385.
Pubmed: 11160875
DOI: 10.1124/mol.59.2.375
Research Highlights
An original mistake With central hypothyroidism in homozygotes and hyperthyrotropinemia in heterozygotes, the TRHR deficiency seen in a consanguineous family suggests compensatory increase of TSH with diminished biopotency.
García, Marta, et al. "Central hypothyroidism due to a TRHR mutation causing impaired ligand affinity and transactivation of Gq." The Journal of Clinical Endocrinology & Metabolism 102.7 (2017): 2433-2442.
Pubmed:
28419241
DOI:
10.1210/jc.2016-3977
Peng, Xiao, Tiejian Li, and John D. Albertson. "Investigating predictability of the TRHR seasonal precipitation at long lead times using a generalized regression model with regularization." Frontiers in Earth Science 9 (2021): 724599.
