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    mProX™ Human TREM2 Stable Cell Line

    [CAT#: S01YF-1023-PY293]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;BV-2
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    CNS Research
    Related Diseases
    Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2; Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1
    Gene ID
    Human:54209
    UniProt ID
    Human:Q9NZC2

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    TREM2 (triggering receptor expressed on myeloid cells 2) is a protein involved in neuroinflammation and neurodegenerative diseases, particularly Alzheimer's disease (AD). It plays a role in the interaction between the central nervous system and the immune system, and its dysfunction is associated with the accumulation of toxic proteins in the brain. Studies have shown that TREM2 can regulate tau phosphorylation and cognitive deficits in AD, and its activation may be a potential therapeutic intervention. Additionally, TREM2 has been implicated in healthy aging, inflammation, metabolism, and cognitive decline. Agonistic antibodies targeting TREM2 are being explored as a therapeutic option for AD. Furthermore, TREM2 has been investigated as a potential biomarker and therapeutic target in COVID-19, as its expression is upregulated in patients and correlates with disease severity.

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    FAQ

    chat Taylor Jones (Verified Customer)

    What is the significance of TREM2 in Alzheimer's disease? Aug 10 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TREM2 plays a critical role in Alzheimer's disease by influencing microglial response to amyloid-beta and regulating calcium signaling in microglia, which affects neuroinflammation and disease progression . Aug 10 2023

    chat Casey Garcia (Verified Customer)

    How does TREM2 affect obesity? Mar 18 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TREM2 expression levels have been found to correlate with body mass index, indicating its role in obesity, particularly in a gender-specific manner. Mar 18 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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