mProX™ Human TREM2 Stable Cell Line

Zhang, Xingyu. et al. "Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease." Nature communications, 2023.
The transmembrane protein, Triggering receptor expressed on myeloid cells 2 (TREM2), is predominantly expressed by microglia in the brain. When proteolytically shed, TREM2 releases a soluble form known as sTREM2. Studies have shown that levels of sTREM2 are increased in the cerebrospinal fluid of patients with Alzheimer's disease (AD), but it is unclear whether sTREM2 plays a role in the disease's pathogenesis. The authors of this study have identified transgelin-2 (TG2), expressed on neurons, as the receptor for sTREM2. They found that microglia-derived sTREM2 binds to TG2, leading to RhoA phosphorylation and inactivation of the RhoA-ROCK-GSK3β pathway. This process decreases tau protein phosphorylation, which is associated with AD. Their research also identified a specific fragment of sTREM2, sTREM2 (77-89), as the active sequence responsible for activating TG2. This segment mimics the effects of sTREM2 on reducing tau phosphorylation. Additional experiments in mice showed that overexpression of sTREM2 or administration of the active peptide improved tau pathology and behavioral impairment in a mouse model of tau pathology. Collectively, these findings suggest that the interaction between sTREM2 and TG2 serves as a means of communication between microglia and neurons. The researchers propose that targeting sTREM2 or its active peptides may be a potential therapeutic approach for treating tauopathies, including AD.
Zhang, Xingyu. et al. "Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease." Nature communications, 2023.
Pubmed: 37865646   DOI: 10.1038/s41467-023-42505-x

Evans, Frances. et al. "CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline." Cell reports, 2023.
Recent discoveries have indicated a potential role for immune receptors in various aging-related functions, including energy regulation, inflammation, and cognitive deterioration. One such receptor, CD300f, bears strong resemblance to the TREM2 lipid-sensing receptor and uniquely combines both activating and inhibitory cell signaling mechanisms to influence inflammation, efferocytosis, and microglial metabolic health. The authors propose that CD300f may serve as a regulator of systemic aging processes and contribute to overall longevity. To test this hypothesis, multiple groups of two strains of mice lacking CD300f were closely monitored over an extended period.
Evans, Frances. et al. "CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline." Cell reports, 2023.
Pubmed: 37864797   DOI: 10.1016/j.celrep.2023.113269