mProX™ Human TPR Stable Cell Line

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;A549;HeLa

Target Classification

Kinase Cell Lines

Target Research Area

Metabolic Research

Related Diseases

Intellectual Developmental Disorder, Autosomal Recessive 79; Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

Gene ID

Human:7175

UniProt ID

Human:P12270

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The application of TPR (Tongue Pressure Resistance) can be summarized as follows: In a study conducted on nasopharyngeal carcinoma patients with dysphagia, a novel system with multisite flexible sensors was used to measure tongue pressure changes. The study found that tongue pressure significantly decreased in patients with dysphagia, with the most pronounced drop in pressure observed in the posterior tongue region (TPR). The study suggests that attention should be paid to pressure training of the TPR during treatments. Additionally, the study found that the endurance time of the anterior and central tongue regions increased significantly, indicating compensation for bolus transport. Therefore, clinical rehabilitation strategies should focus on increasing endurance time training in patients to improve the effectiveness of the swallowing process.

Protocols

Please visit our protocols page.

Customer Reviews

There are currently no Customer reviews or questions for mProX™ Human TPR Stable Cell Line (S01YF-1023-PY143). Click the button above to contact us or submit your feedback about this product.

FAQ

chat Jordan Williams (Verified Customer)

What is the function of the TPR protein in cells? Mar 25 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

TPR plays a crucial role in protecting cells from RNA-mediated replication stress and is involved in mRNA export and gene expression regulation. Mar 25 2021

chat Cameron Miller (Verified Customer)

How does TPR affect mRNA and lncRNA export? Jan 24 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

TPR is required for the efficient nuclear export of mRNAs and lncRNAs, especially from short and intron-poor genes. Jan 24 2020

Published Data

Fig.1 Knocking down Tpr results in a notable decrease in the levels of nuclear pore proteins.

HeLa, HEK293T, and A549 cell lines underwent transfection with two distinct RNA duplexes, one being a control siRNA duplex and the other Tpr siRNA (Tpr RNAi), over a 72-hour period. Subsequently, the cells were subjected to immunofluorescence analysis, focusing on the visualization of Tpr and mAb414 (a nuclear pore marker), and the nucleus was stained with DAPI. Notably, the results were depicted in images, with scale bars indicating a measurement of 10 μm.

Ref: Funasaka, Tatsuyoshi, Eriko Tsuka, and Richard W. Wong. "Regulation of autophagy by nucleoporin Tpr." Scientific reports 2.1 (2012): 878.

Pubmed: 23170199

DOI: 10.1038/srep00878

Research Highlights

Hammedi, Tijani. et al. "Study of the catalytic wet air oxidation of p-hydroxybenzoic acid on a fresh ruthenium catalyst supported by different oxides." Heliyon, 2023.
In a batch reactor at 140 °C and 50 bar total air pressure, p-hydroxybenzoic acid (p-HBA) underwent catalytic wet air oxidation (CWAO) using Ru-based catalysts supported on TiO2, CeO2-TiO2, ZrO2-TiO2, and La2O3-TiO2 materials, all featuring mesopores and pollutant adsorption capabilities. These supports, synthesized via the sol-gel method and impregnated with 3 wt% Ru precursor, were extensively characterized using various techniques including N2-sorption, XRD, XPS, H2-TPR, NH3-TPD, TEM, and HAADF-STEM. The study discussed the relationship between catalytic performance and physicochemical attributes, highlighting the superior activity of cerium-containing catalysts (Ru/CeTi) over Ru/TiO2, Ru/ZrTi, and Ru/LaTi catalysts. The enhanced catalytic properties of Ru catalysts with cerium were attributed to acidic sites and surface oxygen facilitating p-HBA molecule interaction and surface oxygen trapping through the cerium redox process (Ce3+/Ce4+). Furthermore, cerium's presence increased surface-active oxygen, preventing carbon deposition on the Ru catalyst surface, with the pseudo-second order (PSO) model fitting the kinetic data of the p-HBA oxidation reaction using Ru catalysts effectively.
Hammedi, Tijani. et al. "Study of the catalytic wet air oxidation of p-hydroxybenzoic acid on a fresh ruthenium catalyst supported by different oxides." Heliyon, 2023.
Pubmed: 37867862 DOI: 10.1016/j.heliyon.2023.e20875

Salimi, Saeideh. et al. "Engineered Catalyst Based on MIL-68(Al) with High Stability for Hydrogenation of Carbon Dioxide and Carbon Monoxide at Low Temperature." Inorganic chemistry, 2023.
In recent years, there has been a growing recognition of the critical need to reduce and convert carbon dioxide (CO2) emissions. This shift towards a more environmentally-conscious approach has been driven by a variety of factors, including concerns about climate change and the impact of human activities on the environment. As such, there has been a significant focus on developing and implementing strategies to decrease CO2 emissions and find sustainable alternatives. This emphasis on reducing carbon emissions reflects the global commitment to mitigating the effects of climate change.
Salimi, Saeideh. et al. "Engineered Catalyst Based on MIL-68(Al) with High Stability for Hydrogenation of Carbon Dioxide and Carbon Monoxide at Low Temperature." Inorganic chemistry, 2023.
Pubmed: 37856844 DOI: 10.1021/acs.inorgchem.3c01094