mProX™ Human TNK1 Stable Cell Line

[CAT#: S01YF-1023-PY116]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX510	Magic™ Human TNK1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;BxPC-3;MIA PaCa-2;PANC-1;AsPC-1;SU.86.86

Target Classification

Kinase Cell Lines

Gene ID

Human:8711

UniProt ID

Human:Q13470

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TNK1 (thirty-eight negative kinase 1) is a nonreceptor tyrosine kinase that is implicated in cancer progression. It has been found to have a regulatory role in TNK1 activity and stability through its ubiquitin-associated (UBA) domain. The UBA domain of TNK1 binds to polyubiquitin and may be selective for the length and linkages of polyubiquitin chains. Disruption of the UBA domain in TNK1 and its sister kinase, ACK1, can lead to hyperactivation of the kinase. Additionally, the noncatalytic regions of TNK1 are important for its activity and substrate specificity. Understanding the mechanisms of TNK1 activation and regulation could have implications for targeted therapy in cancer treatment.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Skyler Garcia (Verified Customer)

How is TNK1 activation linked to lymphomas? Jul 26 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

TNK1 can become a hyperactive oncogenic kinase due to gene truncation or point mutations that disrupt its 14-3-3 binding site, which is common in lymphomas. Jul 26 2022

chat Skyler Brown (Verified Customer)

What role does TNK1 play in ubiquitin sensing? Aug 02 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

TNK1 acts as a ubiquitin sensor, and its oncogenic activation is controlled by its ability to bind ubiquitin. Aug 02 2023

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