mProX™ Human TLR9 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Toll-like receptor 9 (TLR9) is a protein encoded by the TLR9 gene and is a member of the toll-like receptor (TLR) family. TLR9 plays a significant role in the immune system, particularly in dendritic cells, macrophages, natural killer cells, and other antigen-presenting cells. This receptor is primarily found on endosomes and binds to DNA, especially DNA containing unmethylated CpGs of bacterial or viral origin. When activated, TLR9 triggers signaling cascades leading to a pro-inflammatory cytokine response. This mechanism is vital for the body's defense against infections. Furthermore, TLR9 has been associated with various diseases, including cancer, autoimmune diseases, and infections. For instance, TLR9 expression can be modulated by cancer, infection, and tissue damage. In the context of autoimmune diseases, TLR9 plays a role in conditions like systemic lupus erythematosus (SLE). There is ongoing research into synthetic TLR9 agonists and antagonists to regulate autoimmune inflammation. Additionally, TLR9 has been identified as a potential therapeutic target in oncogenic viral infections, such as human papilloma virus (HPV) and hepatitis B virus (HBV). The receptor's ability to recognize and bind to specific DNA sequences makes it a crucial player in the body's defense mechanisms and a focal point in scientific research.