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    mProX™ Human TLR8 Stable Cell Line

    [CAT#: S01YF-1023-PY214]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HL-60;OCI-AML-3
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Immunodeficiency 98 With Autoinflammation, X-Linked; Anemia, Autoimmune Hemolytic
    Gene ID
    Human:51311
    UniProt ID
    Human:Q9NR97

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Toll-like receptor 8 (TLR8) shares similarities with TLR7 in recognizing single-stranded RNA. However, its specific role and significance in the immune system have distinct nuances. Recent studies have shown that TLR8 plays a role in recognizing viral infections, including SARS-CoV-2 and HIV-1. Moreover, TLR8 mutations have been associated with autoimmune and autoinflammatory disorders, suggesting its intricate role in immune regulation. Given its importance in recognizing viral pathogens, TLR8 is being explored as a potential therapeutic target in antiviral strategies.

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    FAQ

    chat Taylor Davis (Verified Customer)

    How does simvastatin affect TLR8 signaling? May 22 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Simvastatin inhibits TLR8 signaling in human monocytes, which may partly explain its anti-inflammatory effects. This mechanism of action of simvastatin on TLR8 signaling is previously unrecognized. May 22 2020

    chat Skyler Williams (Verified Customer)

    What is the role of UNC93B1 in TLR8-mediated signaling? Nov 09 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    UNC93B1 is crucial for TLR8 localization to the early endosome and the ER, regulating TLR8-mediated signaling in human monocytes. This finding indicates a differential regulation of TLR localization for each TLR. Nov 09 2021

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