mProX™ Human TGFBR1 Stable Cell Line

Product Information

Target Protein

TGFBR1

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

SK-HEP1; HepG2; Hep3B; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research; Metabolic Research

Related Diseases

Multiple Self-Healing Squamous Epithelioma; Loeys-Dietz Syndrome

Gene ID

7046

UniProt ID

P36897

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The TGFBR1 gene codes for the protein known as TGF-β receptor type 1 (transforming growth factor-beta). This receptor uses a mechanism known as signal transduction to transfer signals from the cell surface inside the cell. This kind of signaling allows the external environment to influence internal processes within the cell, such as promoting cell division and growth. TGF-β receptor type 1 traverses the cell membrane to perform signaling. TGF-β receptor type 1's extracellular domain is bound by a protein known as TGF-β, which activates the receptor and permits it to bind to other cell surface receptors. These three proteins combine to produce a complex that activates other proteins in the TGF-β pathway, a signaling pathway that leads to signal transduction. The customized TGFBR1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Jessica

I recently purchased the TGFBR1 KO cell line, and it has been a valuable tool in my laboratory work. Oct 29 2021

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chat Shirley

The human TGFBR1 cell line design is well-optimized, and the provided documentation is comprehensive. It has saved me time and effort compared to traditional methods. Jun 09 2021

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Characterization of HCC cell lines.

7 HCC cell lines were characterized for TGF-β pathway protein expression (TGFBR1, TGFΒR2, Smad2, Smad3, Smad4, Smad7) and TGF-β dependent effects on cell proliferation in order to select the most appropriate models to study TGF-β inhibitors, given the dual role of TGF-β, displaying either cytostatic or pro-tumorogenic properties.

Ref: Serova, Maria, et al. "Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients." Oncotarget 6.25 (2015): 21614.

Pubmed: 26057634

DOI: 10.18632/oncotarget.4308

Research Highlights

The findings reevaluate the significance of TGFBR1 and TGFBR2 as significant genes in MFS patients and imply that genetic polymorphisms in TGFBR1/2 may be involved in regulating the degree of cardiovascular manifestation in MFS.
De Cario, Rosina, et al. "Role of TGFBR1 and TGFBR2 genetic variants in Marfan syndrome." Journal of vascular surgery 68.1 (2018): 225-233.
Pubmed: 28847661 DOI: 10.1016/j.jvs.2017.04.071

This study demonstrates that TFAP2C stimulated the growth of tumors by upregulating TGFBR1, which in turn activated PAK1 signaling.
Kim, Wanyeon, et al. "TFAP2C-mediated upregulation of TGFBR1 promotes lung tumorigenesis and epithelial-mesenchymal transition." Experimental & molecular medicine 48.11 (2016): e273-e273.
Pubmed: 27885255 DOI: 10.1038/emm.2016.125