mProX™ Human TBXA2R Stable Cell Line
[CAT#: S01YF-0923-KX12]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
TBXA2R
Target Family
Prostanoid Family
Target Protein Species
Human
Host Cell Type
Hs578T, MDA-MB-231, MDA-MB-468; SUM-PT-149; CHO-K1; HEK293
Target Classification
GPCR Cell Lines
Target Research Area
Cardiovascular Research; Inflammation Research
Related Diseases
Bleeding Disorder; Phenytoin Allergy
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The G protein-coupled α isoform of the thromboxane receptor (TPα receptor), among other cell surface receptors, controls platelet function. The human TPα receptor, the first cloned human eicosanoid receptor, is a typical Class A rhodopsin-like G protein-coupled receptor (GPCR) with sequence variants in TBXA2R, which encodes the TPα receptor linked to atopic dermatitis, asthma, an autosomal dominant bleeding disorder. The TPα receptor's ligand, thromboxane A2 (TXA2), is produced by the platelet's oxidative metabolism of arachidonic acid and stimulates TP receptors in an autocrine fashion. As a result of the stimulation of Gq/11 and G12/13 heterotrimeric G proteins, RhoA and phospholipase C are activated, promoting platelet activation. The most often given antiplatelet medication, aspirin, targets the TXA2 pathway by irreversibly inhibiting cyclooxygenase enzymes (COX-1), which reduce platelet TXA2 synthesis and stimulate the TPα receptor. The customized TBXA2R stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Nicholas
I purchased the mProX™ Human TBXA2R Stable Cell Line hoping it would meet my project requirements.
Mar 17 2022
Verified Customer
Emma
The TBXA2R cell line demonstrated remarkable specificity and sensitivity, which helped us unravel complex signaling pathways.
Oct 05 2022
Verified Customer
FAQ
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