mProX™ Human TACR2 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types
S01YF-1122-KX654	Magic™ Mouse TACR2 in Vitro Calcium Flux Assay	Mouse	CHO-K1	Calcium Flux Assay
S01YF-1122-KX655	Magic™ Rhesus monkey TACR2 in Vitro Calcium Flux Assay	Rhesus monkey	CHO-K1	Calcium Flux Assay
S01YF-1122-KX656	Magic™ Rat TACR2 in Vitro Calcium Flux Assay	Rat	CHO-K1	Calcium Flux Assay

Product Information

Target Protein

TACR2

Target Family

Tachykinin Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research

Related Diseases

Baritosis; Asthma

Gene ID

6865

UniProt ID

P21452

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Tachykinin neuropeptide substance K is a receptor for the protein TACR2, which can interact with G proteins to activate the phosphatidylinositol-calcium second messenger pathway. It also has something to do with GPCR signaling and peptide ligand-binding receptors. Recent research suggests that it is linked to a wide range of illnesses, including Asthma and Retinitis Pigmentosa 68. In actuality, TACR2 has a big impact on GI motility, secretion, and visceral sensitivity. Numerous other conditions, such as uterine leiomyomas, colorectal cancer, and Alzheimer's disease, have also been linked to the TACR2. In clinical therapy, TACR2 receptor antagonists have been used. The customized TACR2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

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FAQ

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Published Data

Fig.1 Human DCs induce both NK2R and TAC1 gene after IFN-g or poly I:C stimulation.

Human DCs made from PBMC adherent cells were either left untreated (control) or given IFN-𝛾 or poly I:C for a 24-hour period. Confocal microscopy was used to compare the amounts of hNK2R protein expression in the control (left panel) and IFN-𝛾-treated (right panel) human DCs.

Ref: Kitamura, Hidemitsu, et al. "Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor." The Journal of Immunology 188.9 (2012): 4200-4208.

Pubmed: 22474018

DOI: 10.4049/jimmunol.1102521

Research Highlights

Here, they characterize a new mouse strain with congenital Tacr2 ablation to examine the physiological roles of NK2R in controlling the reproductive axis. Similar to agonists of NK1R and NK3R, activation of NK2R in control mice induced acute luteinizing hormone (LH) responses.
Torres, Encarnacion, et al. "Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis." American Journal of Physiology-Endocrinology and Metabolism 320.3 (2021): E496-E511.
Pubmed: 33427049 DOI: 10.1152/ajpendo.00346.2020

In vitro and in vivo, Tacr2 negatively impacted the expression of nNOS and VIP. Its ablation in mice increased the expression of nNOS and VIP, improved NO signaling, and altered the Creb and NF-κB signaling, ultimately resulting in the disruption of stomach emptying in Tacr2-/- animals.
Mao, Y-L., et al. "Ablation of Tacr2 in mice leads to gastric emptying disturbance." Neurogastroenterology & Motility 29.11 (2017): e13117.
Pubmed: 28585346 DOI: 10.1111/nmo.13117