mProX™ Human SUCNR1 Stable Cell Line

Product Information

Target Protein

SUCNR1

Target Family

Succinate Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cardiovascular Research; Digestive and Renal Research

Related Diseases

Renovascular Hypertension; Mooren's Ulcer

Gene ID

56670

UniProt ID

Q9BXA5

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The SUCNR1 gene, which makes up the largest group of membrane proteins in the human genome, codes for the protein succinate receptor 1 (SUCNR1). SUCNR1 promotes the growth of hematopoietic progenitor cells and may play a part in renovascular hypertension, which has been linked to renal failure, diabetes, and atherosclerosis in the past. One condition that SUCNR1 is linked to is Exudative Vitreoretinopathy 1. Peptide ligand-binding receptors and the cAMP signaling pathway are two of its associated pathways. An essential SSUCNR1 paralog is OXGR1. Furthermore, SUCNR1, like P2Y12, 13, and 14, links to Gi/o nearly exclusively, unlike P2Y1-like receptors, which preferentially stimulate Gq signaling and cause calcium release. The customized SUCNR1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Rose

The SUCNR1 cell line is suitable for our drug screening. Jan 16 2023

chat Verified Customer

chat Leopold

Very easy to use for drug screening assay. May 18 2023

chat Verified Customer

FAQ

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Published Data

Fig.1 LysM-Cre Sucnr1fl/fl mice are refractory to prolonged cold-induced browning in scWAT.

Representative pictures of UCP1 immunohistochemistry staining in BAT from two separate experiments, as well as immunoblot quantification of UCP1 protein in BAT (right) and the ratio of UCP1/FAA conducted (middle).

Ref: Keiran, Noelia, et al. "SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity." Nature immunology 20.5 (2019): 581-592.

Pubmed: 30962591

DOI: 10.1038/s41590-019-0372-7

Research Highlights

This study demonstrated that dietary succinate induces tuft and goblet cell hyperplasia via Sucnr1 and the gustducin and Trpm5 chemosensory signaling molecules that are specifically expressed in intestinal tuft cells but not in other types of intestinal epithelial cells.
Lei, Weiwei, et al. "Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine." Proceedings of the National Academy of Sciences 115.21 (2018): 5552-5557.
Pubmed: 29735652 DOI: 10.1073/pnas.1720758115

SUCNR1 has a great deal of promise as a novel pharmacological target and is presumably a key regulator of fundamental physiology. More specialized pharmacological tools, such as small-molecule modulators, will be a valuable asset in the effort to fully characterize this receptor.
Gilissen, Julie, et al. "Insight into SUCNR1 (GPR91) structure and function." Pharmacology & therapeutics 159 (2016): 56-65.
Pubmed: 26808164 DOI: 10.1016/j.pharmthera.2016.01.008