mProX™ Human STK3 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Patrick Liam (Creative Biolabs Scientific Support)
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Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 Knockdown of STK3 in GC cell lines.
Significant reduction in STK3 protein expression was observed in NCI-N87 and MKN28 cells following siSTK3 transfection.
Ref: Chen, Bonan, et al. "STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker." Molecular cancer 20.1 (2021): 1-8.
Pubmed: 34772410
DOI: 10.1186/s12943-021-01451-2
Research Highlights
Ma, Xiao. et al. "Comprehensive split TEV based protein-protein interaction screening reveals TAOK2 as a key modulator of Hippo signalling to limit growth." Cellular signalling, 2023.
The Hippo signaling pathway, a conserved mechanism with a critical role in limiting tissue growth and proliferation, is fundamental in tumorigenesis. At its core, tumor suppressor kinases STK3/4 and LATS1/2 regulate the oncogene YAP1. A protein-protein interaction screen involving 28 key Hippo pathway components and potential regulators unveiled TAOK2 as a central modulator. TAOK2 binds to and phosphorylates LATS1, reducing YAP1 phosphorylation and oncogene transcription, ultimately decreasing cell proliferation and migration. Notably, reduced TAOK2 expression correlates with shorter patient survival in specific cancers, highlighting its role as a tumor suppressor gene. Targeting TAOK2 presents a promising pharmacological avenue to modulate cell growth and combat cancer.
Ma, Xiao. et al. "Comprehensive split TEV based protein-protein interaction screening reveals TAOK2 as a key modulator of Hippo signalling to limit growth." Cellular signalling, 2023.
Pubmed:
37813295
DOI:
10.1016/j.cellsig.2023.110917
Zhu, Jianguo. et al. "Prolactin promotes crop epithelial proliferation of domestic pigeons (Columba livia) through the Hippo signaling pathway." Journal of animal science, 2023.
This study aimed to explore the influence of prolactin (PRL) on pigeon crop epithelium proliferation via the Hippo signaling pathway during the breeding cycle. Twenty-four pairs of adult pigeons were categorized into different breeding stages, with corresponding crop and serum samples collected. Additionally, eighteen pairs of young pigeons underwent injection experiments. The findings revealed significant increases in serum PRL levels and crop epithelial thickness at day 17 of incubation (I17) and day 1 of chick-rearing (R1). Gene expression profiles and protein levels in males and females exhibited distinct patterns, with subcutaneous PRL injections stimulating crop epithelium proliferation through enhanced CTGF expression and reduced YAP phosphorylation, while YAP-TEAD inhibitor verteporfin inhibited this process. In summary, PRL plays a role in pigeon crop cell proliferation by modulating YAP and CTGF expression within the Hippo pathway.
Zhu, Jianguo. et al. "Prolactin promotes crop epithelial proliferation of domestic pigeons (Columba livia) through the Hippo signaling pathway." Journal of animal science, 2023.
Pubmed:
37721785
DOI:
10.1093/jas/skad312
