mProX™ Human STING1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

STING1, also known as Stimulator of Interferon Genes, is a crucial protein in the human body that plays a pivotal role in the innate immune response to cytosolic DNA. When DNA is detected in the cytoplasm, STING1 becomes activated, leading to the production of type I interferons and other pro-inflammatory cytokines. This mechanism is essential for the body's defense against viral infections and certain bacterial infections. Moreover, STING1 has been identified as a potential therapeutic target for autoimmune diseases, where the immune system mistakenly attacks the body's own cells. This is because aberrant activation of STING1 can lead to excessive inflammation, contributing to the pathogenesis of these diseases. Additionally, the STING1 pathway has been implicated in cancer, particularly in the context of the tumor microenvironment. Activation of STING1 in tumor cells can lead to an immune response against the tumor, making it a promising target for cancer immunotherapy. Recent research has also highlighted the role of STING1 in cardiovascular diseases, neurodegenerative diseases, and metabolic disorders, underscoring its importance in various physiological and pathological processes.