mProX™ Human SSTR4 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX957	Magic™ Rat SSTR4 in Vitro cAMP Assay	Rat	CHO-K1	cAMP Assay

Product Information

Target Protein

SSTR4

Target Family

Somatostatin Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research; CNS Research

Related Diseases

Prolactinoma; Hormone Producing Pituitary Cancer

Gene ID

6754

UniProt ID

P31391

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Somatostatins are peptide hormones that control a variety of cellular processes and prevent the secretion of several hormones and other secretory proteins. By inhibiting adenylyl cyclase, G proteins mediate the function of SSTR4. It is functionally linked to both the stimulation of arachidonate release and the mitogen-activated protein (MAP) kinase cascade in addition to the inhibition of adenylate cyclase. According to the study, SSTR4 belongs to a superfamily of receptors with seven transmembrane segments that are most highly expressed in fetal and adult brain and lung. The hypothalamic receptors SSTR1, SSTR2, and SSTR4 were believed to mediate opposing effects through various signal transduction processes, with SST1 and SST4 increasing the response to glutamate. The customized SSTR4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Renee

We are very happy with the product and the turn around time, and would therefore order another reagent. Feb 16 2023

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FAQ

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Published Data

Fig.1 SSTR4 and dOR heterodimerization in cultured striatal neurons.

In cotransfected HEK-293 cells, a histogram showing the relative FRET efficiency is shown. In its initial state, SSTR4/dOR occurs as preformed heterodimers. Keep in mind the decrease in relative FRET efficiency when SST or SSTR4 specific agonists are present. The relative FRET efficiency was increased by SB-205607 alone or in conjunction with SST or L-803087.

Ref: Somvanshi, Rishi K., and Ujendra Kumar. "δ-opioid receptor and somatostatin receptor-4 heterodimerization: Possible implications in modulation of pain associated signaling." PLoS One 9.1 (2014): e85193.

Pubmed: 24416361

DOI: 10.1371/journal.pone.0085193

Research Highlights

By reducing neuronal apoptosis and damage and decreasing CUL4B expression and SSTR ubiquitination degradation, TMP may enhance the cognitive function of AD mice. This work might present a fresh therapeutic approach to treating AD.
Weng, Guohu, et al. "Tetramethylpyrazine improves cognitive function of Alzheimer's disease mice by regulating SSTR4 ubiquitination." Drug Design, Development and Therapy (2021): 2385-2399.
Pubmed: 34103899 DOI: 10.2147/DDDT.S290030

This study validates earlier findings about the relationship between ACEs and overall self-efficacy and a risk for suicide. Additionally, SSTR4 rs2567608 TT patients with AD may be more susceptible to ACEs and have a higher chance of attempting suicide.
Berent, Dominika, et al. "SSTR4, childhood adversity, self-efficacy and suicide risk in alcoholics." Translational neuroscience 8.1 (2017): 76-86.
Pubmed: 28924491 DOI: 10.1515/tnsci-2017-0013