mProX™ Human SPHK2 Stable Cell Line

[CAT#: S01YF-1023-PY102]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX491	Magic™ Human SPHK2 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;Huh-7

Target Classification

Kinase Cell Lines

Target Research Area

Immunology Research

Related Diseases

Ureteral Obstruction; Dermatitis, Atopic, 7

Gene ID

Human:56848

UniProt ID

Human:Q9NRA0

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

SPHK2 (sphingosine kinase 2) has various applications in different fields. In the context of alcoholic liver disease (ALD), targeting SPHK2 with red rice seed coat extract (RRA) was found to improve gut microbiota composition, restore intestinal barrier, and decrease lipopolysaccharide (LPS) levels, thereby ameliorating ALD. In pulmonary hypertension (PH), the SPHK2/S1P axis was found to promote smooth muscle cell histone acetylation, leading to vascular remodeling. In prostate cancer, inhibiting SPHK1/2 with SKI-178 was shown to inhibit cancer cell growth and migration. Additionally, novel SPHK2 inhibitors were designed and synthesized for potential antitumor activity. Lastly, miR-137 was found to be downregulated in glioma and targeting SPHK2 with miR-137 promoted M1-type tumor-associated macrophage polarization, suggesting its potential as a diagnostic biomarker and therapeutic strategy for glioma treatment.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Jordan Jones (Verified Customer)

How does SPHK2 contribute to gastric cancer progression? Feb 19 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2. Feb 19 2023

chat Skyler Johnson (Verified Customer)

What is the impact of miR-153-3p on SPHK2 in gastric cancer? Oct 04 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

miR-153-3p attenuates the development of gastric cancer by suppressing SPHK2. Oct 04 2021

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