mProX™ Human SLC39A6 Stable Cell Line

Product Information

Target Protein

SLC39A6

Target Family

SLC Transporter

Target Protein Species

Human

Host Cell Type

Eca-109; EC9706; CHO-K1; HEK293

Target Classification

Transporter Cell Lines

Target Research Area

Inflammation Research

Related Diseases

Acrodermatitis Enteropathica; Ehlers-Danlos Syndrome

Gene ID

25800

UniProt ID

Q13433

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Transporter of zinc The SLC39A6 gene in humans encodes the protein ZIP6. A vital cofactor for hundreds of enzymes is zinc. It has a role in the regulation of gene transcription, growth, development, and differentiation in addition to the metabolism of proteins, nucleic acids, carbohydrates, and lipids. SLC39A6 is a member of a protein subfamily that exhibits zinc transporter structural traits. The customized SLC39A6 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Michelle

The SLC39A6 overexpression cell line often used in our laboratories. Mar 01 2021

chat Verified Customer

chat Jennifer

The SLC39A6 cell line is a good product for general routine use from Creative Biolabs. Jun 23 2022

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Knockdown of SLC39A6 inhibits cell growth and enhances cell apoptosis in vitro.

Following a 72-hour transfection of Eca-109 and EC9706 cells with either SLC39A6-siRNA or control siRNA, the cells were harvested, and total cellular protein was subjected to the recommended western blotting procedure using an anti-SLC39A6 antibody. β-actin functioned as an internal regulator.

Ref: Cui, Xiao-Bin, et al. "SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma." Journal of translational medicine 13.1 (2015): 1-16.

Pubmed: 26444413

DOI: 10.1186/s12967-015-0681-z

Research Highlights

The current study's findings indicated that SLC39A6 is linked to the growth, migration, and invasion of liver cancer and may be a viable predictive biomarker for the disease.
Wan, Zhen, and Xuzhen Wang. "Role of SLC39A6 in the development and progression of liver cancer." Oncology Letters 23.3 (2022): 1-13.
Pubmed: 35111246 DOI: 10.3892/ol.2022.13197

The underlying molecular pathways of esophageal squamous cell carcinoma (ESCC), a disease that is extremely deadly, are not well understood. A region within the SLC39A6 gene that confers susceptibility to ESCC has been discovered through recent extensive genome-wide association studies conducted on Chinese Han populations.
Cui, Xiao-Bin, et al. "SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma." Journal of translational medicine 13.1 (2015): 1-16.
Pubmed: 26444413 DOI: 10.1186/s12967-015-0681-z