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    mProX™ Human S1PR4 Stable Cell Line

    [CAT#: S01YF-0923-PY103]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    S1PR4
    Target Family
    Lysophospholipid Family
    Target Protein Species
    Mouse
    Host Cell Type
    Primary;microglia;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research;CNS Research
    Related Diseases
    Dermatitis, Atopic, 7
    Gene ID
    Mouse: 13611
    UniProt ID
    Mouse: Q9Z0L1

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    S1PR4, also known as sphingosine-1-phosphate receptor 4, plays a pivotal role in various physiological processes. Recent research has delved into its significance in the immune system, particularly in modulating immune cell trafficking. S1PR4's involvement in the regulation of lymphocyte egress from lymphoid organs has been a focal point of many studies. This receptor has also been associated with the pathogenesis of several diseases, including autoimmune disorders. Its potential as a therapeutic target is being explored, with the aim of developing novel treatments for conditions like multiple sclerosis and other inflammatory diseases.

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    FAQ

    chat Elizabeth (Verified Customer)

    What role does S1PR4 play in the recruitment of macrophages in a murine psoriasis model? Feb 12 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    S1PR4 activation enhances the TLR response of resident macrophages to increase CCL2 production, which in turn attracts more macrophages. This mechanism may be targeted to reduce perpetuating inflammatory responses in conditions like psoriasis. Feb 12 2020

    chat Sandra (Verified Customer)

    How is S1PR4 associated with the activation of fibroblast-like synoviocytes and the IL-17/STAT3 signaling pathway? Jan 05 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The silencing of S1PR4 represses the activation of fibroblast-like synoviocytes by regulating the IL-17/STAT3 signaling pathway. This suggests that inhibitors for S1PR4 might be a potentially promising strategy for the treatment of rheumatoid arthritis. Jan 05 2021

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