mProX™ Human S1PR3 Stable Cell Line

Product Information

Target Protein

S1PR3

Target Family

Lysophospholipid Family

Target Protein Species

Human

Host Cell Type

U2OS;MNNG-HOS;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Immunology Research;CNS Research

Related Diseases

Dermatitis, Atopic, 7;Pulmonary Edema

Gene ID

Human: 1903

UniProt ID

Human: Q99500

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

S1PR3, or sphingosine-1-phosphate receptor 3, has been implicated in a range of physiological and pathological processes. Its role in obesity-induced metabolic dysfunction has been a subject of recent research, where it was found to be involved in regulating key metabolic pathways. Moreover, its involvement in the regulation of the blood-brain barrier, especially after cerebral ischemia/reperfusion, has been highlighted. In the context of cancer, S1PR3 has been associated with renal cell carcinoma progression, emphasizing its potential as a therapeutic target.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Sarah (Verified Customer)

How does S1PR3 contribute to the aggressive behavior observed in obesity-lymphoma? Jul 11 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling have been implicated in the aggressive tumor growth pattern observed in obesity-lymphoma. Targeting the S1P pathway could potentially offer effective and immune-enhancing therapeutic strategies against obesity-lymphomagenesis. Jul 11 2022

chat Ashley (Verified Customer)

What role does S1PR3 play in the proliferation of pericytes and its implications for spinal cord injury? May 21 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

S1P/S1PR3 signaling mediates the proliferation of pericytes through the Ras/pERK pathway. The compound CAY10444 has shown beneficial effects in enhancing neuronal survival, reducing glial scar formation, and improving locomotion recovery after spinal cord injury. May 21 2020

mProX™ Human S1PR3 Stable Cell Line

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Product Information

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Protocols

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