mProX™ Human RXRG Stable Cell Line

Product Information

Target Protein

RXRG

Target Family

Retinoid X Receptor

Target Protein Species

Human

Host Cell Type

MDA-MB-231; MCF-7; CHO-K1; HEK293

Target Classification

Nuclear Receptor

Target Research Area

Cancer Research; Cardiovascular Research

Related Diseases

Hyperlipidemia; Lung Cancer

Gene ID

6258

UniProt ID

P48443

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The RXRG gene in humans codes for the nuclear receptor known as retinoid X receptor gamma, or RXR-gamma. A member of the nuclear receptor family known as retinoid X receptor (RXR) family, which is implicated in mediating the antiproliferative actions of retinoic acid (RA), is encoded by this gene. Together with the thyroid hormone, vitamin D, and retinoic acid receptors, this receptor produces heterodimers that enhance transcriptional activity on the corresponding response element as well as DNA binding. Non-small cell lung cancer cells express this gene at much lower levels. Different isoforms encoded by alternative transcriptional splice variants have been identified and described. The customized RXRG stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Dorothy

This is a very reliable RXRG overexpression cell line with high sensitivity and specificity, suitable for experiments such as flow cytometry. Aug 02 2022

chat Verified Customer

chat Michelle

The RXRG cell line has not disappointed. It consistently delivers accurate results, making my work much more impactful. Feb 02 2020

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FAQ

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Published Data

Fig.1 Western blot and immunohistochemical expression of RXRG in breast cancer.

RXRG expression in MCF-7 and MDA-MB231 breast cancer cell lines was detected by Western blotting with a rabbit polyclonal antibody. RXRG and housekeeping Beta-Actin are represented by green and red bands, respectively.

Ref: Joseph, Chitra, et al. "Retinoid X receptor gamma (RXRG) is an independent prognostic biomarker in ER-positive invasive breast cancer." British Journal of Cancer 121.9 (2019): 776-785.

Pubmed: 31558802

DOI: 10.1038/s41416-019-0589-0

Research Highlights

RXRG stimulates the differentiation of chicken ESCs into PGCs by positively regulating the PPAR signaling pathway. Therefore, the regulation of PGC differentiation in chickens can be studied using gene RXRG.
Cheng, Shaoze, et al. "RXRG associated in PPAR signal regulated the differentiation of primordial germ cell." Journal of Cellular Biochemistry 119.8 (2018): 6926-6934.
Pubmed: 29738084 DOI: 10.1002/jcb.26891

A member of the nuclear receptor superfamily, retinoid X receptor gamma (RXRG) is involved in the suppression of tumors. The purpose of this study is to investigate the prognostic relevance of RXRG in breast cancer.
Joseph, Chitra, et al. "Retinoid X receptor gamma (RXRG) is an independent prognostic biomarker in ER-positive invasive breast cancer." British Journal of Cancer 121.9 (2019): 776-785.
Pubmed: 31558802 DOI: 10.1038/s41416-019-0589-0