mProX™ Human RXRA Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The RXRA gene in humans codes for the nuclear receptor known as retinoid X receptor alpha (RXR-alpha). Nuclear receptors called retinoid X receptors (RXRs) and retinoic acid receptors (RARs) participate in retinoic acid-mediated gene activation, which mediates the biological effects of retinoids. By attaching as homodimers or heterodimers to particular regions in the promoters of target genes, these receptors control the transcription of the target genes. The protein that this gene encodes belongs to the superfamily of transcription factors that includes thyroid hormone and steroid receptors. The RXR-RAR heterodimers bind to a multiprotein complex that contains transcription corepressors when there is no ligand present. This complex causes chromatin condensation, transcriptional suppression, and histone deacetylation. Transcriptional activation results from the corepressors' separation from receptors upon ligand binding and their association with coactivators. The customized RXRA stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.