mProX™ Human RXFP1 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types
S01YF-1122-KX853	Magic™ Dog RXFP1 in Vitro cAMP Assay	Dog	CHO-K1	cAMP Assay
S01YF-1122-KX856	Magic™ Rabbit RXFP1 in Vitro cAMP Assay	Rabbit	CHO-K1	cAMP Assay
S01YF-1122-KX857	Magic™ Rat RXFP1 in Vitro cAMP Assay	Rat	CHO-K1	cAMP Assay

Product Information

Target Protein

RXFP1

Target Family

Relaxin Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Reproductive Research

Related Diseases

Endometriosis; Placenta Accreta

Gene ID

59350

UniProt ID

Q9HBX9

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The placenta and ovarian corpora lutea in females, as well as the prostate in males, are the primary sites for the production of relaxin, a small heterodimeric peptide hormone of the insulin/relaxin superfamily. RXFP1 is a cognate receptor of RLN that is produced in the placenta and is also known as leucine-rich repeat G-protein coupled receptor (LGR7). In rodents, the endothelium and vascular smooth muscle of the systemic vasculature express RLN and RXFP1, but in humans, the umbilical endothelium and vascular smooth muscle express RXFP1. Furthermore, as a receptor for the relaxin protein hormone, RXFP1 is essential for sperm motility, pregnancy, and parturition. This gene's reduced expression may contribute to endometriosis. The customized RXFP1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Grace

The RXFP1 cell line was easy to use, and the support team was responsive to our inquiries. Nov 25 2022

chat Verified Customer

chat Samuel

We used the RXFP1 cell line for target validation in our drug development project, and it performed flawlessly. Apr 02 2023

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 RXFP1 expression

Rat myometrium, rat cervix, and mouse cervix RXFP1 protein characterization. Instead of the primary antibody, rabbit IgG was employed in the negative-control blot. The protein bands' molecular weights are expressed in kDa.

Ref: Vodstrcil, Lenka A., et al. "Decreased expression of the rat myometrial relaxin receptor (RXFP1) in late pregnancy is partially mediated by the presence of the conceptus." Biology of reproduction 83.5 (2010): 818-824.

Pubmed: 20686184

DOI: 10.1095/biolreprod.110.083931

Research Highlights

Signaling by the relaxin/relaxin family peptide receptor 1 (RXFP1) is crucial for both healthy physiology and illness. Relaxin is a potent antifibrotic chemical, according to strong preclinical evidence.
Chen, Ting-Yun, et al. "The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease." Molecular Genetics & Genomic Medicine 8.4 (2020): e1194.
Pubmed: 32100955 DOI: 10.1002/mgg3.1194

According to this research, the cadherin/catenin complex, which is broken down by β-catenin phosphorylation via RLN2/RXFP1 signaling, weakens adherens junctions in cancer cells.
Fue, Misaki, et al. "Relaxin 2/RXFP1 signaling induces cell invasion via the β-catenin pathway in endometrial cancer." International journal of molecular sciences 19.8 (2018): 2438.
Pubmed: 30126180 DOI: 10.3390/ijms19082438