mProX™ Human RPS6KB1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

RPS6KB1 (ribosomal protein S6 kinase B1) is a protein kinase that plays a role in various cellular processes and pathways in different contexts. In pancreatic cancer, RPS6KB1 is involved in sustaining the activation of MTORC1 (mechanistic target of rapamycin kinase complex 1) by regulating the transcription of FNIP1 and FNIP2, which promote the recruitment of MTORC1 to the lysosome. The activation of MTORC1 is critical for cell growth and is frequently observed in cancer. In hepatic steatosis induced by fructose, RPS6KB1 is implicated in the perturbation of cellular proteostasis, resulting in the expression of pro-lipogenic genes, specifically fatty acid synthase (FASN). RPS6KB1 is also associated with the pathophysiology of perinatal hypoxia, where it influences gene regulation, transcription, translation, and stemness. In lactating Holstein cows during periods of negative nutrient balance, RPS6KB1 is part of the signaling pathway in the liver that is responsive to post-ruminal choline supply. Lastly, in glioblastoma (GBM), RPS6KB1 inhibition, along with CDK7 and CDK9, shows potential as a therapeutic strategy for both TMZ-sensitive and resistant GBM by suppressing tumor growth and interfering with transcription, translation, and stemness.