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    mProX™ Human PVR Stable Cell Line

    [CAT#: S01YF-1023-PY174]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;CT26;SW620
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Infectious Research
    Related Diseases
    Poliomyelitis; Paralytic Poliomyelitis
    Gene ID
    Human:5817
    UniProt ID
    Human:P15151

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    PVR, or pars plana vitrectomy, is a surgical procedure used in the repair of rhegmatogenous retinal detachment (RRD) in patients with nystagmus. A study found that while RRD repair had a 100% success rate in reattaching the retina, it can be challenging in patients with nystagmus, with complications such as recurrent retinal detachment due to retinal breaks. Another study proposed an integrated model of the maternal cardiac-placental-fetal array in the development of preeclampsia, classifying it into Type I and Type II based on different phenotypes and proposed origins. PVR was also used in the quantitative analysis of chest computed tomography for assessing the severity of COVID-19 pneumonia. Additionally, PVR was evaluated in the management patterns of male urethral stricture disease, with the study finding that most urologists still prefer other methods over urethroplasty. Finally, PVR was used in the intravascular ultrasound-guided stent implantation in the left main coronary artery compression caused by pulmonary artery aneurysm in a patient with Eisenmenger syndrome.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Cameron Miller (Verified Customer)

    How does PVR contribute to proliferative vitreoretinopathy (PVR)? Jan 09 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    EMP2, a protein associated with PVR, correlates with the severity of the disease, suggesting a potential therapeutic target for controlling retinal pigment epithelium biology in PVR. Jan 09 2022

    chat Alex Davis (Verified Customer)

    What is the role of PVR in TIGIT-mediated immune checkpoint blockade? Feb 12 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The TIGIT-CD226-PVR axis is crucial in immune checkpoint blockade, with PVR playing a significant role in TIGIT-mediated inhibition of immune responses, advancing cancer immunotherapy. Feb 12 2020

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