mProX™ Human PTGFR Stable Cell Line

Product Information

Target Protein

PTGFR

Target Family

Prostanoid Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Reproductive Research; Ocular Research

Related Diseases

Ocular Hyperemia; Ocular Hypertension

Gene ID

5737

UniProt ID

P43088

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The prostaglandin (PG) group of receptors includes PTGFR, sometimes referred to as the prostaglandin F receptor (FP). PTGFR binds to prostaglandin F2α (PGF2α) and regulates its biological effects. It is thought to be the most effective therapeutic target out of the nine prostanoid receptors. Humans who use PTGFR receptor agonists on their eyelashes may have hyperpigmentation in nearby skin areas as a side effect. PTGFR receptor activation may be a practical way to improve skin pigmentation, according to studies. In addition, PGF2α restricts airways in both healthy and asthmatic people, and its presence in human sputum is associated with eosinophil levels in the same fluid. In terms of blood pressure, cardiac function, and atherosclerosis, PTGFR activation has pathologic effects on the cardiovascular system in animal models. The customized PTGFR stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Ryan

I have always got fast and friendly response from Creative biolabs. Sep 05 2022

chat Verified Customer

chat Audrey

I am happy for the service and the product. The web-page is easy to navigate in order to choose the product. Jun 24 2022

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Activation of the PGF2α-PTGFR

On postnatal day 16, Ptgfr mRNA expression was present in each retinal layer of normoxic and OIR mice. With isolectin B4-stained arteries in green, DAPI-stained nuclei in blue, and LCM isolation locations circled by white dashed circles, the left-hand figure shows representative cross-sections from OIR and normoxic retinas.

Ref: Zhao, Yan, et al. "PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR+ CXC chemokine expression." EMBO Molecular Medicine 15.1 (2023): e16373.

Pubmed: 36511116

DOI: 10.15252/emmm.202216373

Research Highlights

In order to better understand how intraocular pressure (IOP) response to latanoprost in POAG patients may be correlated with common single nucleotide polymorphisms (SNPs) in the AFAP1, GMDS, and PTGFR genes, this study looked into this possibility.
Cui, X-J., A-G. Zhao, and X-L. Wang. "Correlations of AFAP 1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma." Journal of clinical pharmacy and therapeutics 42.1 (2017): 87-92.
Pubmed: 27862086 DOI: 10.1111/jcpt.12468

For spermatogenesis and steroidogenesis, prostaglandins (PGs) and prostaglandin endoperoxide synthase (PTGS) are thought to be important.
Körber, H., and S. Goericke-Pesch. "Expression of PTGS2, PGFS and PTGFR during downregulation and restart of spermatogenesis following GnRH agonist treatment in the dog." Cell and tissue research 375.2 (2019): 531-541.
Pubmed: 30198052 DOI: 10.1007/s00441-018-2915-x