mProX™ Human PTGER2 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The human gene PTGER2 encodes PTGER2, a 53 kDa prostaglandin receptor for prostaglandin E2 (PGE2). In humans, PTGER2 is widely distributed. The human small intestine, lung, uterus, thymus, cerebral cortex, corneal epithelium, and other organs all express it. The PTGER2 receptor performs a number of tasks. Rodents, cats, rhesus monkeys, and humans all saw a reduction in intraocular pressure when the PTGER2 receptor was topically given to their eyes. This effect appears to be caused, at least in part, by PTGER2. According to studies, female mice that have been genetically altered to be deficient in the PTGER2 gene have a mildly reduced rate of ovulation and a significantly reduced ability to become pregnant. Additionally, PTGER2 activation affects allergy and inflammatory responses. The PTGER2 receptor can also stimulate tumor growth. Additionally, following exposure to carcinogens, lung, breast, skin, and colon cancers are less common in PTGER2 gene knockout mice. The customized PTGER2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.