mProX™ Human PTGDR Stable Cell Line

Product Information

Target Protein

PTGDR

Target Family

Prostanoid Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Inflammation Research; Reproductive Research

Related Diseases

Asthma-Related Traits; Asthma

Gene ID

5729

UniProt ID

Q13258

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The PTGDR gene encodes the prostanoid D receptor (PGD2 receptor), also known as PTGDR. The PTGDR molecule has a molecular weight of 40.28 kDa and 359 amino acids. It has seven transmembrane domains, a configuration found in heterotrimeric G proteins that function as signaling receptors. Through linkage and association studies, the prostaglandin D2 receptor (PTGDR) gene has been linked to asthma and related symptoms. Functional studies using animal models and additional expression studies based on in vitro cell models also suggest a potential role for polymorphisms in the promoter region, in the differential binding of transcription factors, and consequently in PTGDR expression, which appear to be linked to the development of asthma or to susceptibility to the disease. The customized PTGDR stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat LiLi

I customized a PTGDR overexpression cell line and it was verified that the product meets my requirement. Oct 31 2022

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chat Christopher

This cell line is very suitable for studying the PTGDR signaling pathway. Jan 15 2023

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FAQ

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Published Data

Fig.1 qPCR evaluation of PTGDR gene expression in PBMCs from allergic patients following ATRA, DMSO, or antagonist therapy.

Before inducing with ATRA or DMSO and performing a qPCR study of PTGDR, PBMC containing the mutation -549T or -549C were pre-treated with 1 mM of Pan RAR-antagonist for 1 hour. At 48 hours, cells were harvested. The control group of cells received DMSO treatment.

Ref: Garcia-Sanchez, Asuncion, et al. "PTGDR expression is upregulated through retinoic acid receptors (RAR) mechanism in allergy." Plos one 14.4 (2019): e0215086.

Pubmed: 30986261

DOI: 10.1371/journal.pone.0215086

Research Highlights

Allergy and PTGDR overexpression are related. PTGDR expression has the potential to be a pharmacogenetic and biomarker in allergy.
Segundo-Val, San, et al. "Promoter Genotyping and mRNA Expression-Based Analysis of the PTGDR Gene in Allergy." Journal of Investigational Allergology & Clinical Immunology 30.2 (2019): 117-126.
Pubmed: 31062691 DOI: 10.18176/jiaci.0411

Prostaglandin D Receptor (PTGDR) gene promoter polymorphisms may play a role in asthma, according to functional investigations. It is possible that PTGDR-mediated RAR regulation affects Th2 responses, indicating that RAR may be a promising therapeutic target in allergic inflammation.
Garcia-Sanchez, Asuncion, et al. "PTGDR expression is upregulated through retinoic acid receptors (RAR) mechanism in allergy." Plos one 14.4 (2019): e0215086.
Pubmed: 30986261 DOI: 10.1371/journal.pone.0215086