mProX™ Human PROM1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PROM1, also known as Prominin-1, is a gene that has been studied in various medical contexts. In one study, PROM1 was found to be associated with pigment epithelial detachment (PED) in age-related macular degeneration (AMD). The researchers established a polygenic risk score using PROM1 and other non-coding variants to predict the risk of PED occurrence. Another study focused on PROM1 in KMT2A-rearranged acute lymphoblastic leukemia (ALL). The researchers found that acquired resistance to a DOT1L inhibitor in pediatric KMT2A::AFF1+ B-ALL cells led to a loss of PROM1 expression, indicating the adaptive potential of these leukemia cells. Additionally, PROM1 was investigated in high-grade serous ovarian cancer (HGSOC). The study found that PROM1 mRNA and protein levels were associated with clinical outcomes, such as chemotherapy response, overall survival, and disease-free survival. Finally, PROM1 was studied in mouse retinal pigment epithelial (RPE) cells. Loss of Prom1 function impaired autophagy and promoted epithelial-mesenchymal transition (EMT) in these cells, suggesting its role in RPE homeostasis and retinal degenerative diseases.