mProX™ Human PRKCZ Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX446	Magic™ Human PKCζ(PRKCZ) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;SK-OV-3;OVCAR-3

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research

Related Diseases

Chromosome 1P36 Deletion Syndrome; Glioblastoma

Gene ID

Human:5590

UniProt ID

Human:Q05513

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKCZ (protein kinase C zeta) has been identified as a potential biomarker in various studies. In the context of Alzheimer's disease, a deep learning model incorporating KEGG pathway constraints on genotyping data identified PRKCZ as one of the genes with a significant impact on disease prediction. In a study on macrophages stimulated by an antimicrobial peptide, PRKCZ was found to be differentially expressed and potentially involved in immune responses. In the field of cardiovascular diseases, PRKCZ was identified as a gene associated with differential methylation in patients with acute coronary syndrome. Additionally, in a study on sheep, PRKCZ was one of the genes associated with wool production traits. Finally, in the context of tuberculosis, PRKCZ was identified as one of the key genes that could participate in the pathogenesis of the disease. These findings suggest that PRKCZ may have implications in disease diagnosis, immune response, cardiovascular health, and wool production.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Cameron Brown (Verified Customer)

How does PRKCZ hypermethylation influence HPV-related head and neck squamous cell carcinoma? Mar 12 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

PRKCZ hypermethylation in HPV-related head and neck squamous cell carcinoma inhibits invasion and epithelial-mesenchymal transition via Cdc42. Mar 12 2020

chat Jordan Brown (Verified Customer)

What is the role of PRKCZ in acute coronary syndrome? Aug 21 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

PRKCZ DNA methylation is a potential epigenetic-sensitive target in acute coronary syndrome, indicating its role in the pathogenesis. Aug 21 2022

Published Data

Fig.1 Knockdown of PRKCZ in ovarian cancer cell lines.

PRKCZ protein expression was assessed by western blot analysis using PRKCZ-specific antibodies in SKOV3 parental control (PC), control vector (N2), and a range of PRKCZ clone samples.

Ref: Seto, Kelly KY, and Irene L. Andrulis. "Atypical protein kinase C zeta: potential player in cell survival and cell migration of ovarian cancer." PloS one 10.4 (2015): e0123528.

Pubmed: 25874946

DOI: 10.1371/journal.pone.0123528

Research Highlights

Jemimah, Sherlyn; AlSheh, Aamna. "c-Diadem: a constrained dual-input deep learning model to identify novel biomarkers in Alzheimer's disease." BMC medical genomics, 2023.
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder with no known cure. Current diagnostic biomarkers for AD are expensive and invasive, making early detection difficult. To address this issue, a team of researchers is proposing a new approach called "c-Diadem" (constrained dual-input Alzheimer's disease model), which uses deep learning technology and incorporates KEGG pathway constraints to predict AD or cognitive normality based on genetic data. They also utilized SHAP to explain the model and potentially identify new blood-based genetic markers for AD. This innovative method could facilitate less-invasive and routine diagnostic tests for early intervention.
Jemimah, Sherlyn; AlSheh, Aamna. "c-Diadem: a constrained dual-input deep learning model to identify novel biomarkers in Alzheimer's disease." BMC medical genomics, 2023.
Pubmed: 37833700 DOI: 10.1186/s12920-023-01675-9

Qin, Ting. et al. "Comprehensive analysis of lncRNA and mRNA expression profile of macrophage RAW264.7 stimulated by antimicrobial peptide BSN-37." Protein and peptide letters, 2023.
BSN-37, a newly discovered antimicrobial peptide (AMP) consisting of 37 amino acid residues extracted from the bovine spleen, has demonstrated both antibacterial and immunomodulatory properties. According to recent research, long non-coding RNAs (lncRNAs) play a significant role in regulating immune cell activation and function. To further explore the impact of BSN-37 on immune cells, a study was conducted to assess the expression profile of lncRNAs and mRNAs in mouse macrophages RAW264.7 stimulated by BSN-37. This experiment aimed to shed light on the effects of BSN-37 on immune cell function.
Qin, Ting. et al. "Comprehensive analysis of lncRNA and mRNA expression profile of macrophage RAW264.7 stimulated by antimicrobial peptide BSN-37." Protein and peptide letters, 2023.
Pubmed: 37587823 DOI: 10.2174/0929866530666230816110009