mProX™ Human PRKCE Stable Cell Line

[CAT#: S01YF-1023-PY65]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX445	Magic™ Human PKCε(PRKCE) in Vitro Assay	Human		Kinase Assay
S01YF-1222-KX460	Magic™ Human PRKCE in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;NOD;GBC-SD

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research;Ocular Research

Related Diseases

Short Syndrome; Ischemia

Gene ID

Human:5581

UniProt ID

Human:Q02156

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKCE (Protein Kinase C-epsilon) has been studied in various applications, including cervical cancer, amyotrophic lateral sclerosis (ALS), triple-negative breast cancer (TNBC), and sighthound genetics. In cervical cancer, PRKCE variants have been associated with the disease and its clinicopathological features, suggesting their potential use as prognostic markers and therapeutic targets. In ALS, the impaired expression of PKCŒµ in the motor cortex has been observed, and its activation by Bryostatin-1 has shown long-term survival in degenerating motor neurons. In TNBC, siRNA-7, which targets PRKCE among other cancer-related genes, has exhibited significant efficacy in inhibiting cell viability, making it a potential therapeutic candidate. In sighthounds, multiple origins of the breed have been identified, and PRKCE has been found to be under positive selection, suggesting its role in the morphology of sighthound genomes. Overall, PRKCE has shown promise in various fields, including cancer research and neurodegenerative diseases.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Skyler Davis (Verified Customer)

What is the significance of the WWTR1-PRKCE fusion in uterine leiomyoma? Mar 28 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

The WWTR1-PRKCE fusion, resulting from a cryptic translocation, may play a role in the pathogenesis of uterine leiomyoma with 3q- as the sole visible chromosome abnormality. Mar 28 2022

chat Alex Smith (Verified Customer)

How do non-coding variants of PRKCE influence its gene transcription and translation? Jan 22 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Non-coding variants of PRKCE can influence the activity of transcription factors, promoting gene transcription and impacting diseases. Jan 22 2022

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