mProX™ Human PRKCA Stable Cell Line

[CAT#: S01YF-1023-PY61]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX440	Magic™ Human PKCα(PRKCA) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;MDA-MB-231;MCF-7;4T1

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research;CNS Research

Related Diseases

Chordoid Glioma; Cryptosporidiosis

Gene ID

Human:5578

UniProt ID

Human:P17252

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKCA (Protein Kinase C Alpha) has been identified as a potential target in the treatment of nonalcoholic fatty liver disease (NAFLD) and liver cancer. In the study on NAFLD, PRKCA was one of the core targets of naringenin, a compound being investigated for NAFLD treatment. The study on liver cancer found that PRKCA was one of the key target proteins associated with the efficacy of Zuogui Pill, a traditional Chinese medicine used in liver cancer treatment. Both studies highlighted the multi-target and multi-pathway nature of PRKCA's therapeutic effects. Additionally, PRKCA was also found to be involved in lipid metabolism and obesity, as well as in the pathogenesis of growth-disordered raccoon dogs infected with Eperythrozoon. These findings suggest that PRKCA may have potential applications in the development of new drugs for liver diseases and as a therapeutic target for liver cancer and growth disorders.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Peyton Williams (Verified Customer)

How does PRKCA influence acute lung injury? Jun 28 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

PRKCA is involved in alleviating acute lung injury by inhibiting proinflammatory cytokine release via macrophages and the MAPK signaling pathway. Jun 28 2023

chat Alex Smith (Verified Customer)

What is the role of PRKCA in non-small cell lung cancer? May 05 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

PRKCA plays a role in the progression of non-small cell lung cancer, as evidenced by studies showing that curcumin can inhibit cancer progression by downregulating circ-PRKCA. May 05 2020

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