mProX™ Human PBK Stable Cell Line

[CAT#: S01YF-1023-PY47]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX422	Magic™ Human PBK in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;MDA-MB-231

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research;Ocular Research

Related Diseases

Central Corneal Ulcer; Perforated Corneal Ulcer

Gene ID

Human:55872

UniProt ID

Human:Q96KB5

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PBK, or PDZ-binding kinase, has various applications in different fields. In the field of reproductive health, PBK has been studied in relation to premature ovarian insufficiency (POI). Researchers have identified PBK as one of the hub genes associated with the pathogenesis of POI. In pancreatic cancer research, CRISPR/Cas9-mediated knockout of CD73, a gene highly expressed in pancreatic cancer, revealed that PBK is a possible regulator of CD73. Andrographolide, a compound with hepatoprotective properties, has been found to target PBK in protecting against liver injury induced by lipopolysaccharide (LPS). Additionally, in toxicology studies, PBK has been used as a target in predicting acute paraquat toxicity. Overall, PBK plays a role in various biological processes and can be targeted for different applications, including reproductive health, cancer treatment, liver protection, and toxicity prediction.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Smith (Verified Customer)

What is the role of PBK in colorectal cancer? Sep 15 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

PBK enhances cellular proliferation and suppresses migration and invasion in colorectal cancer, indicating its potential as a therapeutic target. Sep 15 2022

chat Peyton Garcia (Verified Customer)

How does PBK affect renal cell carcinoma (RCC) and its resistance to sorafenib? Feb 14 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

PBK is involved in sorafenib resistance in RCC by being phosphorylated by ERK2, which promotes tumorigenesis. Feb 14 2020

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