mProX™ Human PAK6 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Patrick Liam (Creative Biolabs Scientific Support)
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Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 HeLa cell proliferation in response to PAK6 expression level knockdown.
Colony formation assays were employed to assess the proliferative rate of HeLa cells transfected with shPAK6, with a subsequent semi-quantitative analysis of colony numbers conducted.
Ref: Yang, Qin, et al. "PAK6 promotes cervical cancer progression through activation of the Wnt/β‑catenin signaling pathway." Oncology Letters 20.3 (2020): 2387-2395.
Pubmed: 32782556
DOI: 10.3892/ol.2020.11797
Research Highlights
Xue, Song-Tao et al. "Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis." Molecular cancer vol. 21,1 69. 7 Mar. 2022.
In the realm of esophageal squamous cell carcinoma (ESCC), an abundant long non-coding RNA (lncRNA), LINC00680, has emerged as a significant player, showcasing heightened expression levels associated with larger tumor size, advanced disease stage, and bleak prognoses. Extensive investigations revealed its pivotal role in promoting ESCC progression. LINC00680, acting as a competitive endogenous RNA (ceRNA), sequesters miR-423-5p, thus facilitating the expression of PAK6 (p21-activated kinase 6) in ESCC cells. This intricate interplay influences cell proliferation, colony formation, migration, and invasion, both in vitro and in vivo. Moreover, the use of antisense oligonucleotides (ASOs) targeting LINC00680 demonstrates substantial therapeutic potential in restraining ESCC progression. Altogether, these findings illuminate LINC00680/miR-423-5p/PAK6 as promising biomarkers and therapeutic targets in the ESCC landscape.
Xue, Song-Tao et al. "Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis." Molecular cancer vol. 21,1 69. 7 Mar. 2022.
Pubmed:
35255921
DOI:
10.1186/s12943-022-01539-3
Lyu, Yang. et al. "A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province." Animal genetics, 2023.
In recent years, indigenous cattle have played a significant role in providing food and labor for humans. Among these breeds is the Zhaotong cattle, originating from the Yunnan province in China. This breed is known for its superior meat quality and ability to withstand heat and humidity. To understand the genetic composition and potential beneficial traits of Zhaotong cattle, a study was conducted using whole genome sequencing data from 104 animals. The results revealed that Zhaotong cattle have a genetic makeup mainly influenced by Chinese indicine cattle and East Asian cattle. They also have a high nucleotide diversity compared to other taurine cattle. The study also identified several regions in the genome with potential positive selection signals that contain key genes related to bone development, metabolism, meat quality, immune response, and heat resistance. This study provides valuable genetic insights and serves as a foundation for understanding the genetic basis of indigenous cattle breeds.
Lyu, Yang. et al. "A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province." Animal genetics, 2023.
Pubmed:
37796667
DOI:
10.1111/age.13363
